Triterpene Glycosides Tricycloiridals A-D with Cytotoxicity Isolated from Fungus Chrysosporium sp. YX1242
文献类型： 外文期刊
第一作者： Chen, Kang
作者： Chen, Kang;Song, Kainan;Xu, Yuquan;Xu, Yuquan;Jiang, Xianzhi
作者机构：
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）
ISSN： 0163-3864
年卷期： 2025 年 88 卷 7 期
页码：
收录情况： SCI
摘要： Keratinophilic fungi are significant pathogens that cause dermatomycoses. Here, we report the discovery of four novel triterpene glycosides, tricycloiridals A-D (1-4), from the keratinophilic fungus Chrysosporium sp. YX1242, guided by mass-spectrometry-based molecular networking. Their structures, featuring unprecedented triterpene skeletons, were elucidated through comprehensive NMR, HRESIMS, and Snatzke's and advanced Mosher's methods. Notably, compound 1 exhibited potent cytotoxicity against human keratinocytes HaCaT (IC50 = 2.50 +/- 0.2 mu M), suggesting a potential role as a virulence factor in fungal pathogenesis. Additionally, bioinformatic analysis was used to predict the biosynthetic gene cluster responsible for these triterpene glycosides.
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