A novel infectious hematopoietic necrosis virus (IHNV) isolated from white-spotted charr (Salvelinus leucomaenis) is moderately virulent to rainbow trout (Oncorhynchus mykiss)

文献类型： 外文期刊

第一作者： Guan, Chunyan

作者： Guan, Chunyan;Zhao, Jingzhuang;Shao, Yizhi;Lu, Tongyan;Xu, Liming;Zhao, Jingzhuang;Shao, Yizhi;Lu, Tongyan;Xu, Liming;Guan, Chunyan

作者机构：

关键词： White-spotted charr; Rainbow trout; IHNV; J genogroup; Pathogenicity

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）

ISSN： 0044-8486

年卷期： 2025 年 609 卷

页码：

收录情况： SCI

摘要： J genogroup infectious hematopoietic necrosis virus (IHNV) is mostly isolated from rainbow trout (Oncorhynchus mykiss). In this study, a novel IHNV strain, designated as H202217, was isolated from diseased white-spotted charr (Salvelinus leucomaenis). The phylogenetic analysis showed that the H202217 strain had the closest relationship with other Chinese J genogroup IHNV strains isolated from rainbow trout. In vitro proliferation experiments showed that the H202217 strain had lower titer but similar immunogenicity with the Sn1203 strain, a reference strain isolated from rainbow trout. In the artificial infection of white- spotted charr, the H202217 strain showed low virulence, and caused a cumulative percentage of mortality (CPM) of 15 %, which was higher than the CPM of 7.5 % caused by the Sn1203 strain. While challenged in rainbow trout, the H202217 strain caused moderate CPM of 22 %, lower than that of 46 % caused by the Sn1203 strain. In addition, the viral loads of the H202217 strain were higher than those of Sn1203 strain in white-spotted charr, while it was the opposite in the rainbow trout. These results suggest that the H202217 strain has better fitness with white-spotted charr and lost partial virulence to rainbow trout compared with the rainbow trout sourced IHNV Sn1203 strain, and which has potential use to reveal the IHNV virulence evolution companied with host jump in the future.

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