Application of Non-Viral Vectors in Drug Delivery and Gene Therapy

文献类型： 外文期刊

第一作者： Ren, Shuaikai

作者： Ren, Shuaikai;Wang, Mengjie;Wang, Chunxin;Wang, Yan;Sun, Changjiao;Zeng, Zhanghua;Cui, Haixin;Zhao, Xiang

作者机构：

关键词： non-viral vectors; polymers; liposomes; gold nanoparticles; mesoporous silica nanoparticles; carbon nanotubes

期刊名称：POLYMERS （ 影响因子：4.967； 五年影响因子：5.063 ）

ISSN：

年卷期： 2021 年 13 卷 19 期

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收录情况： SCI

摘要： Vectors and carriers play an indispensable role in gene therapy and drug delivery. Non-viral vectors are widely developed and applied in clinical practice due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production. This review summarized a variety of non-viral vectors and carriers including polymers, liposomes, gold nanoparticles, mesoporous silica nanoparticles and carbon nanotubes from the aspects of physicochemical characteristics, synthesis methods, functional modifications, and research applications. Notably, non-viral vectors can enhance the absorption of cargos, prolong the circulation time, improve therapeutic effects, and provide targeted delivery. Additional studies focused on recent innovation of novel synthesis techniques for vector materials. We also elaborated on the problems and future research directions in the development of non-viral vectors, which provided a theoretical basis for their broad applications.

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