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猪APOBEC3F基因外显子6单核苷酸多态性及其与PRRSV易感性的关联分析

文献类型: 中文期刊

作者: 朱前明 1 ; 孟春花 2 ; 李静心 2 ; 王慧利 2 ; 王亚磊 1 ; 王婧 1 ; 茆达干 1 ; 曹少先 1 ;

作者机构: 1.南京农业大学动物科技学院

2.江苏省农业科学院畜牧研究所

关键词: 载脂蛋白B mRNA编辑酶催化多肽3F;CRS-PCR-RFLP;PRRSV;易感性

期刊名称: 畜牧与兽医

ISSN: 0529-5130

年卷期: 2014 年 46 卷 05 期

页码: 48-52

收录情况: 北大核心

摘要: 载脂蛋白B mRNA编辑酶催化多肽3F(APOBEC3F)是有效阻止内源性与外源性反转录病毒复制的新型宿主细胞因子。本文对猪APOBEC3F基因外显子6序列进行扩增和测序,筛选多态性位点,并分析其与PRRSV易感性的相关性。测序发现外显子6存在3个单碱基突变(g.337 T/G、g.341 G/A和g.343 T/C)。针对g.341 G/A建立CRS-PCR-RFLP方法,检测9个猪群193个样本,发现仅在姜曲海猪和梅山猪中有GG(0.79/0.80)和GA(0.21/0.20)基因型,其他7个猪群体只检测到GG基因型。GG基因型猪肺泡巨噬细胞中PRRSV拷贝数在接毒后18h显著高于GA基因型个体(P<0.05)。表明APOBEC3F基因外显子6与猪种PRRSV抗性相关,外显子6的341位点A等位基因更有利于抵抗PRRSV的感染,这为进一步探讨APOBEC3F基因作为猪种PRRSV抗性辅助选育标记提供了试验依据。

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