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Single nucleotide polymorphisms in the 3 ' UTR of follistatin-like 4 and scavenger receptor class B member 1 are associated with Dazu black goat litter size

文献类型： 外文期刊

作者： Zhu, Ji-Yuan 1 ; E, Guang-Xin 2 ; Wang, Jia-Bo 3 ; Xu, Shan-Shan 4 ; Yang, Xiu-Qin 1 ;

作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150006, Peoples R China

2.Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China

3.Southwest Minzu Univ, Key Lab Qinghai Tibetan Plateau Anim Genet Resour, Chengdu 610041, Sichuan, Peoples R China

4.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin 150086, Peoples R China

关键词： goat; litter size; untranslated regions; correlation; single nucleotide polymorphism

期刊名称：CANADIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.077； 五年影响因子：1.281 ）

ISSN： 0008-3984

年卷期：

页码：

收录情况： SCI

摘要： The untranslated regions (UTRs) of genes play crucial roles in regulating gene expression at the post-transcriptional level such as affecting mRNA stabilization. In this study, 26 single nucleotide polymorphisms (SNPs) and one deletion located in UTR were genotyped from 186 Dazu black goats via SNaPshot, and the correlation between genotype and litter size was analyzed. The results indicated that two SNP loci, SNP_chr17-20182525 and SNP_chr7-65652612, which were located at the 3' UTR of scavenger receptor class B member 1 and follistatin-like 4, were significantly (P < 0.05) correlated with the litter size of first parity goats. SNP_chr7-65652612 was also significantly associated with the total litter size of first and second parity offspring (P < 0.05). In conclusion, SNP_chr7-65652612 and SNP_chr17-20182525 have correlation with the litter size of Dazu black goat and they are potential genetic markers for litter size breeding.

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