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Assessment of probiotic Bacillus velezensis supplementation to reduce Campylobacter jejuni colonization in chickens

文献类型： 外文期刊

作者： Cui, Yifang 1 ; Zhu, Jiajia 2 ; Li, Pengxiang 1 ; Guo, Fangfang 1 ; Yang, Bing 1 ; Su, Xia 1 ; Zhou, Hongzhuan 1 ; Zhu, Kui 3 ; Xu, Fuzhou 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Lives, Beijing 100097, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Wuhan 430064, Peoples R China

3.China Agr Univ, Coll Vet Med, Natl Ctr Vet Drug Safety Evaluat, Beijing, Peoples R China

关键词： probiotic; Bacillus velezensis; antimicrobial activity; Campylobacter jejuni; chicken

期刊名称：POULTRY SCIENCE （ 影响因子：3.8； 五年影响因子：4.1 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 8 期

页码：

收录情况： SCI

摘要： Campylobacter jejuni continues to be a major public health issue worldwide. Poultry are recognized as the main reservoir for this foodborne pathogen. Implementing measures to decrease C. jejuni colonization on farms has been regarded as the most effective strategy to control the incidence of campylobacteriosis. The probiotics supplementation has been regarded as an attractive approach against C. jejuni in chickens. Here the inhibitory effects of one probiotic B. velezensis isolate CAU277 against C. jejuni was evaluated in vitro and in vivo. The in vitro antimicrobial activity showed that the supernatant of B. velezensis exhibited the most pronounced inhibitory effects on Campylobacter strains compared to other bacterial species. When co -cultured with B. velezensis , the growth of C. jejuni reduced signi ficantly from 7.46 log 10 CFU/mL (24 h) to 1.02 log 10 CFU/mL (48 h). Further, the antimicrobial activity of B. velezensis against C. jejuni remained stable under a broad range of temperature, pH, and protease treatments. The in vivo experiments demonstrated that oral administration of B. velezensis signi ficantly reduced the colonization of C. jejuni by 2.0 log 10 CFU/g of feces in chicken cecum at 15 d postinoculation. In addition, the supplementary of B. velezensis signi ficantly increased microbial species richness and diversity in chicken ileum, especially enhanced the bacterial population of Alistipes and Christensenellaceae , and decreased the existence of Lachnoclostridium. Our study presents that B. velezensis possesses antimicrobial activities against C. jejuni and promotes microbiota diversity in chicken intestines. These findings indicate a potential to develop an effective probiotic additive to control C. jejuni infection in chicken.

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