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Comparative transcriptomic analysis of hepatopancreas reveals that more genes are involved in the exposure response of Vibrio parahaemolyticus PirAvp vp compared to PirBvp vp

文献类型： 外文期刊

作者： Liu, Hourong 1 ; Jiang, Lijie 1 ; Qin, Chuang 2 ; Min, Xiuwen 2 ; Huang, Yifei 1 ; Chen, Yihong 3 ; Li, Xincang 2 ;

作者机构： 1.Shanghai Customs Coll, Dept Inspect & Quarantine Technol Commun, Shanghai 201204, Peoples R China

2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

3.South China Normal Univ, Inst Modern Aquaculture Sci & Engn IMASE, Coll Life Sci, Guangzhou 510631, Peoples R China

关键词： Litopenaeus vannamei; Vibrio parahaemolyticus; PirAvp/PirBvp toxin; Response mechanism

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 2023影响因子：4.1； 五年影响因子：4.2 ）

ISSN： 1050-4648

年卷期： 2024 年 153 卷

页码：

收录情况： SCI

摘要： Vibrio parahaemolyticus (VP-AHPND) AHPND ) is regarded as one of the main pathogens that caused acute hepatopancreatic necrosis disease (AHPND) in the Pacific white shrimp Litopenaeus vannamei. . PirAvp vp and PirBvp vp toxin proteins are the main pathogenic proteins of AHPND in shrimp. Knowledge about the mechanism of shrimp response to PirAvp vp or PirBvp vp toxin is very helpful for developing new prevention and control strategy of AHPND in shrimp. In this study, the pathological sections showed that after 4 h treatment, significant pathological changes were observed in the PirBvp vp treated group, and no obvious pathological changes was found in PirAvp vp treated group. In order to learn the mechanism of shrimp response to PirAvp vp and PirBvp, vp , comparative transcriptome was applied to analyze the different expressions of genes in the hepatopancreas of shrimp after treatment with PirAvp vp or PirBvp. vp . A total of 9978 differentially expressed genes (DEGs) were identified between PirAvp vp or PirBvp-treated vp-treated and PBS control shrimp, including 6616 DEGs in the PirAvp vp treated group and 3362 DEGs in the PirBvp vp treated group. There were 2263 DEGs that were commonly expressed, 4353 DEGs were only expressed in PirAvp vp VS PBS group and 1099 DEGs were uniquely expressed in PirBvp vp VS PBS group. Among these DEGs, the anti-apoptosis related pathways and immune response related genes significantly expressed in the commonly expressed DEGs of PirAvp vp VS PBS group and PirBvp vp VS PBS group, and small GTPase-mediated signaling and DNA metabolic process might relate to the host special reaction towards PirAvp vp and PirBvp vp exposure. The data suggested that the differential expression of these immune and metabolic-related genes in hepatopancreas might contribute to the pathogenicity variations of shrimp to VP- AHPND . The identified genes in this study will be useful for clarifying the response mechanism of shrimp toward different toxins of VP- AHPND and will further provide molecular basis for understanding the pathogenic mechanism of VP- AHPND .

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