文献类型： 外文期刊

作者： Pang, Yue ¹ ; Qin, Yating ³ ; Du, Zeyu ¹ ; Liu, Qun ³ ; Zhang, Jin ¹ ; Han, Kai ³ ; Lu, Jiali ¹ ; Yuan, Zengbao ³ ; Li, Jun ¹ ; Pan, Shanshan ³ ; Dong, Xinrui ¹ ; Xu, Mengyang ³ ; Wang, Dantong ³ ; Li, Shuo ¹⁰ ; Li, Zhen ³ ; Chen, Yadong ³ ; Zhao, Zhisheng ¹ ; Zhang, Zhe ¹¹ ; Chuan, Shunqin ¹ ; Song, Yue ³ ; Sun, Mingjie ¹ ; Jia, Xiaodong ¹² ; Xia, Zhangyong ¹³ ; Zhan, Liping ³ ; Yue, Zhen ¹⁴ ; Cui, Wei ³ ; Wang, Jun ³ ; Gu, Ying ⁸ ; Ni, Ming ¹¹ ; Yang, Huanming ⁸ ; Xu, Xun ⁸ ; Liu, Xin ⁸ ; Li, Qingwei ¹ ; Fan, Guangyi ³ ;

作者机构： 1.Liaoning Normal Univ, Coll Life Sci, Dalian 116081, Peoples R China

2.Liaoning Normal Univ, Lamprey Res Ctr, Dalian 116081, Peoples R China

3.BGI Res, Qingdao 266555, Peoples R China

4.BGI Res, Qingdao Key Lab Marine Genom, Qingdao 266555, Peoples R China

5.Univ Copenhagen, Dept Biol, DK-2100 Copenhagen, Denmark

6.BGI Res, Hangzhou 310030, Peoples R China

7.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China

8.BGI Res, Shenzhen 518083, Peoples R China

9.BGI Res, Shenzhen Key Lab Marine Biol Genom, Shenzhen 518083, Peoples R China

10.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Shandong, Peoples R China

11.MGI Tech, Shenzhen 518083, Peoples R China

12.Liaocheng Peoples Hosp, Joint Lab Translat Med Res, Liaocheng 252000, Shandong, Peoples R China

13.Second Peoples Hosp Liaocheng, Dept Neurol, Liaocheng 252000, Shandong, Peoples R China

14.BGI Res, Sanya 572025, Peoples R China

15.BGI, Shenzhen 518083, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Lampreys are early jawless vertebrates that are the key to understanding the evolution of vertebrates. However, the lack of cytomic studies on multiple lamprey organs has hindered progress in this field. Therefore, the present study constructed a comprehensive cell atlas comprising 604,460 cells/nuclei and 70 cell types from 14 lamprey tissue samples. Comparison of cellular evolution across species revealed that most lamprey cell types are homologous to those in jawed vertebrates. We discovered acinar- and islet-like cell populations despite the lack of parenchymal organs in lampreys, providing evidence of pancreatic function in vertebrates. Furthermore, we investigated the heterogeneity of lamprey immune cell populations. Natterin was highly expressed in granulocytes, and NATTERIN was localized to the lipid droplets. Moreover, we developed a transgenic mouse model expressing Natterin to elucidate the role of NATTERIN in lipid metabolism, whereas the browning of white adipose tissue was induced. These findings elucidate vertebrate cellular evolution and advance our understanding of adipose tissue plasticity and metabolic regulation in lampreys.