The autophagy-related proteins FvAtg4 and FvAtg8 are involved in virulence and fumonisin biosynthesis in Fusarium verticillioides
文献类型： 外文期刊
作者： Wang, Yujie 1 ; Liu, Xin 2 ; Xu, Yujiao 1 ; Gu, Yiying 1 ; Zhang, Xinyue 1 ; Zhang, Mengxuan 1 ; Wen, Wen 1 ; Lee, Yin-Won 4 ; Shi, Jianrong 2 ; Mohamed, Sherif Ramzy 5 ; Goda, Amira A. 5 ; Wu, Huijun 1 ; Gao, Xuewen 1 ; Gu, Qin 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Dept Plant Pathol, Minist Educ,Key Lab Monitoring & Management, Nanjing, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Safety & Qual Minist Agr & Rural Affairs, Key Lab Agroproduct Safety Risk Evaluat Nanjing, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Nanjing, Jiangsu, Peoples R China
3.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China
4.Seoul Natl Univ, Sch Agr Biotechnol, Seoul, South Korea
5.Natl Res Ctr, Food Toxicol & Contaminants Dept, Giza, Egypt
关键词： Autophagy; Fusarium verticillioides; virulence; fumonisin biosynthesis
期刊名称：VIRULENCE （ 影响因子：5.428； 五年影响因子：6.735 ）
ISSN： 2150-5594
年卷期： 2022 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Autophagy is the main intracellular degradation system by which cytoplasmic materials are transported to and degraded in the vacuole/lysosome of eukaryotic cells, and it also controls cellular differentiation and virulence in a variety of filamentous fungi. However, the contribution of the autophagic pathway to fungal development and pathogenicity in the important maize pathogen and mycotoxigenic fungus Fusarium verticillioides is still unknown. In this study, we characterized two autophagy-related proteins, FvAtg4 and FvAtg8. The F. verticillioides deletion mutants Delta FvAtg4 and Delta FvAtg8 were impaired in autophagosome formation, aerial hyphal formation, sexual growth, lipid turnover, pigmentation and fungal virulence. Interestingly, Delta FvAtg4 and Delta FvAtg8 were defective in fumonisin B1 (FB1) synthesis, which may have resulted from decreased intracellular levels of alanine in the mutants. Our results indicate that FvAtg4 and FvAtg8 contribute to F. verticillioides pathogenicity by regulating the autophagic pathway to control lipid turnover, fumonisin biosynthesis, and pigmentation during its infectious cycle.
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