Gut Microbiota and Its Metabolites Modulate Pregnancy Outcomes by Regulating Placental Autophagy and Ferroptosis
文献类型： 外文期刊
作者： Du, Xingyu 1 ; Elsabagh, Mabrouk 3 ; He, Feiyang 1 ; Wu, Huisi 1 ; Zhang, Bei 1 ; Fan, Kewei 2 ; Wang, Mengzhi 1 ; Zhang, Hao 1 ;
作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Lab Metab Manipulat Herbivorous Anim Nutr, Yangzhou 225009, Peoples R China
2.Longyan Univ, Key Lab Fujian Univ Prevent Vet Med & Biotechnol, Longyan 364012, Peoples R China
3.Nigde Omer Halisdemir Univ, Fac Agr Sci & Technol, Dept Anim Prod & Technol, TR-51240 Nigde, Turkiye
4.Univ Al Dhaid, Coll Agr, POB 27272, Sharjah, U Arab Emirates
5.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China
关键词： autophagy; ferroptosis; gut microbiota; placental development; pregnancy outcomes
期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）
ISSN：
年卷期： 2025 年 14 卷 8 期
页码：
收录情况： SCI
摘要： During pregnancy, the regulation of autophagy and ferroptosis dynamically supports placental development and fetal health. Both processes-autophagy, clearing damaged organelles to maintain placental function, and ferroptosis, driven by iron-dependent lipid peroxidation-are involved in pathological conditions such as preeclampsia. Emerging evidence suggests that gut microbiota-derived metabolites act as key regulators of this balance, yet their specific roles across different trimesters remain unclear. This review compiles evidence on how gut microbiota metabolites, like short-chain fatty acids and trimethylamine N-oxide, serve as trimester-specific modulators of the autophagy-ferroptosis balance during pregnancy. We explain how these metabolites influence pregnancy outcomes by regulating placental autophagy and ferroptosis. Furthermore, we explore potential diagnostic and therapeutic approaches for pregnancy complications, focusing on metabolite-based biomarkers and interventions that target microbial-metabolic interactions.
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