文献类型： 外文期刊

作者： Lin, Yan ¹ ; Miao, Linghong ⁴ ; Li, Xiaoqin ¹ ; Qian, Linjie ⁵ ; Mu, Qiaoqiao ⁵ ; Liu, Bo ⁴ ; Ge, Xianping ⁴ ; Leng, Xiangjun ¹ ;

作者机构： 1.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China

2.Shanghai Ocean Univ, Minist Agr & Rural Affairs, Ctr Res Environm Ecol & Fish Nutr CREEFN, Shanghai 201306, Peoples R China

3.Shanghai Ocean Univ, Shanghai Collaborat Innovat Aquat Anim Genet & Bre, Shanghai 201306, Peoples R China

4.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Minist Agr & Rural Affairs, Key Lab Aquat Anim Nutr & Hlth,Key Lab Freshwater, Wuxi 214081, Peoples R China

5.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China

6.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, 9 Shanshui East Rd, Wuxi 214081, Jiangsu, Peoples R China

7.Shanghai Ocean Univ, Hucheng Ring Rd 999, Shanghai 201306, Peoples R China

关键词： Antioxidant and anti-inflammatory; Endoplasmic reticulum stress; Ferulic acid; Hepato-intestinal health; Growth performance

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：3.8 ）

ISSN： 2352-5134

年卷期： 2023 年 33 卷

页码：

收录情况： SCI

摘要： To investigate the impact of dietary inclusion of ferulic acid (FA) on growth performance, physiological and biochemical functions and hepato-intestinal health, three iso-nitrogenous and iso-lipidic diets supplemented with 0 mg/kg, 100 mg/kg, and 200 mg/kg FA were fed to Megalobrama amblycephala (9.75 +/- 0.04 g) for 8 weeks. The growth performance, physiological and biochemical parameters, antioxidant capacity and the expression of genes were assessed on 4th and 8th week. The results indicated that 100 mg/kg FA inclusion significantly enhanced the weight gain rate (on week 4 and 8), feed intake (on 4th week), protein efficiency ratio (on week 8) and condition factor (on week 4) (P < 0.05). In plasma biochemical index, dietary FA significantly reduced the contents of alanine aminotransferase, glucose and lactate dehydrogenase on 8th week (P < 0.05). In the antioxidant capacity, dietary FA decreased the malondialdehyde (MDA) content in hepatopancreas and intestine (P < 0.05), while increased the activities of total superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione S-transferase (P < 0.05), and the best effects were observed at 100 mg/kg FA inclusion on 8th week. On 8th week, the supplementation of 100 mg/kg FA down-regulated the expression levels of inflammation-related genes (interleukin-6, interleukin-1 beta (hepatopancreas only), nuclear factor-kappa B), pro-apoptotic gene caspase-8 and endoplasmic reticulum stress-related genes (X-box-binding protein 1 S, protein kinase R-like ER kinase, inositol requiring enzyme 1, C/EBP homologous protein, immunoglobulin binding protein (hepatopancreas only), activated transcription factor 6 alpha, activated transcription factor 4) (P < 0.05), while the anti-apoptotic gene B lymphoblastoma-2 was significantly up-regulated (P < 0.05). In conclusion, FA enhanced the growth performance, antioxidant and anti-inflammatory properties, reduced apoptosis level, and maintained the hepato-intestinal endoplasmic reticulum homeostasis. The FA inclusion was suggested at 100 mg/kg.