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Cyclosporin A acts as an insecticide candidate: providing sustainable biocontrol potential for managing Mythimna separata

文献类型： 外文期刊

作者： Sun, Chengxian 1 ; Li, Xin 1 ; Xiao, Zeyu 1 ; Li, Shunjia 1 ; Wang, Kai 1 ; Tian, Caihong 2 ; Feng, Hongqiang 2 ; Liu, Xiaoguang 1 ; Yin, Xinming 1 ; Wei, Jizhen 1 ; Bai, Sufen 1 ; An, Shiheng 1 ;

作者机构： 1.Henan Agr Univ, Coll Plant Protect, State Key Lab Wheat & Maize Crop Sci, Henan Int Lab Green Pest Control, Zhengzhou 450002, Peoples R China

2.Henan Acad Agr Sci, Inst Plant Protect, Zhengzhou 450002, Henan, Peoples R China

关键词： Cyclosporin A; Mythimna separata; Insecticidal activity; Sublethal effects; Campoletis chlorideae

期刊名称：JOURNAL OF PEST SCIENCE （ 影响因子：5.742； 五年影响因子：5.562 ）

ISSN： 1612-4758

年卷期：

页码：

收录情况： SCI

摘要： As a fungal metabolite, cyclosporin A (CsA) is widely used by patients to avoid immune rejection; however, little is known about its insecticidal activity. In this study, Mythimna separata was employed as a model to investigate the insecticidal activity of CsA as a biocontrol factor. The results showed that CsA had strong insecticide activity (LC50 = 19.23 mu g/g for newly hatched larvae) and significantly sublethal effects (especially reproduction suppression) against M. separate. The combined toxicities of CsA with spinosad, azadirachtin, abamectin, and Cry1Ac against M. separata showed independent or synergistic toxicity, suggesting that CsA could be used alone or in a synergistic manner with current insecticides as a pest management strategy and/or to address pest resistance. Subsequent exploration of its insecticidal mechanism indicated that CsA has a unique ability to suppress the activity of calcineurin. An investigation of the use of CsA during indoor breeding of Campoletis chlorideae Uchida (a natural enemy of M. separata) suggested that this metabolite can facilitate the occurrence and reproduction of C. chlorideae. Overall, our study provides information concerning the potential for sustainable biocontrol of M. separata through novel bioinsecticide development; it also provides important clues for improving sustainable management of M. separata and other lepidopterous pest insects.

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