A novel NIR fluorescent probe with ratiometric imaging of cysteine in endoplasmic reticulum
文献类型： 外文期刊
作者： Wang, Ziming 1 ; He, Shenwei 1 ; Xu, Xiujuan 1 ; Xie, Peiyao 1 ; Yan, Hanlei 1 ; Zhang, Di 2 ; Ye, Yong 1 ; Zhao, Yufen 1 ;
作者机构： 1.Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
2.Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China
3.Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China
期刊名称：NEW JOURNAL OF CHEMISTRY （ 影响因子：3.925； 五年影响因子：3.629 ）
ISSN： 1144-0546
年卷期： 2022 年 46 卷 46 期
页码：
收录情况： SCI
摘要： As a significant organelle in cells, endoplasmic reticulum is a cystic, vesicular and tubular structure formed by a single unit membrane. Herein, we develop an endoplasmic reticulum (ER)-targeting NIR probe, HL-Cys, for Cys, which has ratiometrically fluctuating UV-vis absorption and fluorescence spectra with large Stokes shift, with desirable selectivity and sensitivity. Biological imaging demonstrates that HL-Cys could locate in the ER and image Cys levels during ER oxidative stress in HeLa cells.
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