文献类型： 外文期刊

作者： Tong, Xiaoling ¹ ; Han, Min-Jin ¹ ; Lu, Kunpeng ¹ ; Tai, Shuaishuai ³ ; Liang, Shubo ¹ ; Liu, Yucheng ⁴ ; Hu, Hai ¹ ; Shen, Jianghong ¹ ; Long, Anxing ² ; Zhan, Chengyu ¹ ; Ding, Xin ¹ ; Liu, Shuo ¹ ; Gao, Qiang ¹ ; Zhang, Bili ¹ ; Zhou, Linli ¹ ; Tan, Duan ¹ ; Yuan, Yajie ¹ ; Guo, Nangkuo ² ; Li, Yan-Hong ³ ; Wu, Zhangyan ³ ; Liu, Lulu ¹ ; Li, Chunlin ¹ ; Lu, Yaru ¹ ; Gai, Tingting ¹ ; Zhang, Yahui ¹ ; Yang, Renkui ⁵ ; Qian, Heying ⁶ ; Liu, Yanqun ⁷ ; Luo, Jiangwen ¹ ; Zheng, Lu ¹ ; Lou, Jinghou ¹ ; Peng, Yunwu ⁸ ; Zuo, Weidong ¹ ; Song, Jiangbo ¹ ; He, Songzhen ¹ ; Wu, Songyuan ¹ ; Zou, Yunlong ¹ ; Zhou, Lei ¹ ; Cheng, Lan ¹ ; Tang, Yuxia ¹ ; Cheng, Guotao ¹ ; Yuan, Lianwei ¹ ; He, Weiming ³ ; Xu, Jiabao ³ ; Fu, Tao ³ ; Xiao, Yang ⁹ ; Lei, Ting ⁵ ; Xu, Anying ⁶ ; Yin, Ye ³ ; Wang, Jian ¹⁰ ; Monteiro, Antonia ¹² ; Westhof, Eric ¹ ; Lu, Cheng ¹ ; Tian, Zhixi ⁴ ; Wang, Wen ¹⁶ ; Xiang, Zhonghuai ¹ ; Dai, Fangyin ¹ ;

作者机构： 1.Southwest Univ, Inst Sericulture & Syst Biol, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China

2.Southwest Univ, Coll Sericulture Text & Biomass Sci, Key Lab Sericultural Biol & Genet Breeding, Minist Agr & Rural Affairs, Chongqing 400715, Peoples R China

3.BGI Shenzhen, BGI Genom, Shenzhen 518083, Peoples R China

4.Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China

5.Chongqing Sericulture Sci & Technol Res Inst, Chongqing 400715, Peoples R China

6.Jiangsu Univ Sci & Technol, Sch Biotechnol, Jiangsu Key Lab Sericulture Biol & Biotechnol, Zhenjiang 212018, Jiangsu, Peoples R China

7.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 111000, Liaoning, Peoples R China

8.Ankang Univ, Shaanxi Key Lab Sericulture, Ankang 710072, Shaanxi, Peoples R China

9.Guangdong Acad Agr Sci, Inst Sericulture & Agr Prod Proc, Guangzhou 510000, Guangdong, Peoples R China

10.BGI Shenzhen, Shenzhen 518083, Peoples R China

11.James D Watson Inst Genome Sci, Hangzhou 310058, Peoples R China

12.Natl Univ Singapore, Biol Sci, 14 Sci Dr 4, Singapore 117543, Singapore

13.Yale NUS Coll, Sci Div, Singapore 138614, Singapore

14.Univ Strasbourg, Inst Biol Mol & Cellulaire, UPR9002 CNRS, Architecture & Reactivite ARN, F-67084 Strasbourg, France

15.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

16.Northwestern Polytech Univ, Sch Ecol & Environm, Xian 710072, Shaanxi, Peoples R China

17.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Yunnan, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：17.694； 五年影响因子：17.763 ）

ISSN：

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated. The silkworm Bombyx mori is an important economic insect for producing silk, the "queen of fabrics". The currently available genomes limit the understanding of its genetic diversity and the discovery of valuable alleles for breeding. Here, we deeply re-sequence 1,078 silkworms and assemble long-read genomes for 545 representatives. We construct a high-resolution pan-genome dataset representing almost the entire genomic content in the silkworm. We find that the silkworm population harbors a high density of genomic variants and identify 7308 new genes, 4260 (22%) core genes, and 3,432,266 non-redundant structure variations (SVs). We reveal hundreds of genes and SVs that may contribute to the artificial selection (domestication and breeding) of silkworm. Further, we focus on four genes responsible, respectively, for two economic (silk yield and silk fineness) and two ecologically adaptive traits (egg diapause and aposematic coloration). Taken together, our population-scale genomic resources will promote functional genomics studies and breeding improvement for silkworm.