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Mixture toxicity of pyraclostrobine and metiram to the zebrafish (Danio rerio) and its potential mechanism

文献类型： 外文期刊

作者： Wang, Yanhua 1 ; Gao, Zhongwen 2 ; Liu, Chuande 3 ; Mao, Liangang 4 ; Liu, Xinju 1 ; Ren, Jindong 1 ; Lu, Zeqi 3 ; Yao, Jie 3 ; Liu, Xuan 3 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

2.Nankai Univ, Res Inst Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China

3.Yantai Acad Agr Sci, Yantai 265500, Peoples R China

4.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China

关键词： Combined toxicity; Aquatic toxicology; Toxic mechanism; Synergistic action

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：5.8； 五年影响因子：5.4 ）

ISSN： 0944-1344

年卷期： 2023 年 30 卷 15 期

页码：

收录情况： SCI

摘要： The interplay between pesticides plays a critical role in ecotoxicology since these chemicals rarely emerge as single substances but rather in mixtures with other chemicals. In the present work, we purposed to clarify the combined toxic impacts of pyraclostrobine (PYR) and metiram (MET) on the zebrafish by using numerous indicators. Results exhibited that the 4-day LC50 value of MET to fish embryos was 0.0025 mg a.i. L-1, which was lower compared with PYR (0.019 mg a.i. L-1). Combinations of PYR and MET presented a synergetic impact on fish embryos. Contents of POD, CYP450, and VTG were drastically increased in the plurality of the single and joint treatments relative to the baseline value. Three genes, including vtg1, crh, and il-8, related to the endocrine and immune systems, were also surprisingly up-regulated when fish were challenged by the individual and mixture pesticides compared with the baseline value. These results afforded valuable information on the latent toxicity mechanisms of co-exposure for PYR and MET in the early growth stage of fish. Moreover, our data also revealed that frequent application of these two pesticides might exert a potentially ecotoxicological hazard on aquatic ecosystems. Collectively, the present study provided valuable guidance for the risk evaluation of chemical combinations.

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