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Targeting mitochondria with antioxidant nutrients for the prevention and treatment of postweaning diarrhea in piglets

文献类型： 外文期刊

作者： Qiao, Lei 1 ; Dou, Xina 1 ; Song, Xiaofan 1 ; Chang, Jiajing 1 ; Yi, Hongbo 2 ; Xu, Chunlan 1 ;

作者机构： 1.Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China

2.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Anim Breeding & Nutr, State Key Lab Livestock & Poultry Breeding,Minist, Key Lab Anim Nutr & Feed Sci South China,Inst Anim, Guangzhou 510640, Guangdong, Peoples R China

关键词： Post-weaning diarrhea; Piglet; Antioxidant; Nutrient; Mitochondria

期刊名称：ANIMAL NUTRITION （ 影响因子：6.3； 五年影响因子：6.9 ）

ISSN： 2405-6383

年卷期： 2023 年 15 卷

页码：

收录情况： SCI

摘要： Post-weaning diarrhea (PWD) in piglets poses a significant challenge and presents a grave threat to the global swine industry, resulting in considerable financial losses and compromising the welfare of animals. PWD is commonly associated with gut homeostatic imbalance, including oxidative stress, excessive inflammation, and microbiota dysbiosis. Antibiotic use has historically been a common initiative to combat PWD, but concerns about the development of antibiotic resistance have led to increased interest in alternative strategies. Mitochondria are key players in maintaining cellular homeostasis, and their dysfunction is intricately linked to the onset and progression of PWD. Accumulating evidence suggests that targeting mitochondrial function using antioxidant nutrients, such as vitamins, minerals and polyphenolic compounds, may represent a promising approach for preventing and treating PWD. Moreover, nutrients based on antioxidant strategies have been shown to improve mitochondrial func-tion, restore intestinal redox balance, and reduce oxidative damage, which is a key driver of PWD. The present review begins with an overview of the potential interplay between mitochondria and gut ho-meostasis in the pathogenesis of PWD in piglets. Subsequently, alternative strategies to prevent and treat PWD using antioxidant nutrients to target mitochondria are described and discussed. Ultimately, we delve into potential limitations and suggest future research directions in this field for further advancement. Overall, targeting mitochondria using antioxidant nutrients may be a promising approach to combat PWD and provides a potential nutrition intervention strategy for regulating gut homeostasis of weaned piglets.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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