Multi-omics and gut microbiome: Unveiling the pathogenic mechanisms of early-life pesticide exposure
文献类型： 外文期刊
作者： Yue, Yifan 1 ; Sun, Xiaoxuan 1 ; Tian, Sinuo 2 ; Yan, Sen 3 ; Sun, Wei 1 ; Miao, Jiyan 1 ; Huang, Shiran 1 ; Diao, Jinling 1 ; Zhou, Zhiqiang 1 ; Zhu, Wentao 1 ;
作者机构： 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China
3.Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
4.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Yuanmingyuan West Rd 2, Beijing 100193, Peoples R China
关键词： Exposure; Mechanism; Health effects; Pesticides; Microbiome
期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.2； 五年影响因子：4.6 ）
ISSN： 0048-3575
年卷期： 2024 年 199 卷
页码：
收录情况： SCI
摘要： The extensive application of pesticides in agricultural production has raised significant concerns about its impact on human health. Different pesticides, including fungicides, insecticides, and herbicides, cause environmental pollution and health problems for non-target organisms. Infants and young children are so vulnerable to the harmful effects of pesticide exposure that early-life exposure to pesticides deserves focused attention. Recent research lays emphasis on understanding the mechanism between negative health impacts and early-life exposure to various pesticides. Studies have explored the impacts of exposure to these pesticides on model organisms (zebrafish, rats, and mice), as well as the mechanism of negative health effects, based on advanced methodologies like gut microbiota and multi-omics. These methodologies help comprehend the pathogenic mechanisms associated with early-life pesticide exposure. In addition to presenting health problems stemming from early-life exposure to pesticides and their pathogenic mechanisms, this review proposes expectations for future research. These proposals include focusing on identifying biomarkers that indicate early-life pesticide exposure, investigating transgenerational effects, and seeking effective treatments for diseases arising from such exposure. This review emphasizes how to understand the pathogenic mechanisms of early-life pesticide exposure through gut microbiota and multi-omics, as well as the adverse health effects of such exposure.
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