Bifidobacterium mediate gut microbiota-remedied intestinal barrier damage caused by cyproconazole in zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Sun, Xiaoxuan 1 ; Tian, Sinuo 2 ; Yan, Sen 3 ; Sun, Wei 1 ; Miao, Jiyan 1 ; Yue, Yifan 1 ; Han, Shihang 1 ; Huang, Shiran 1 ; Xu, Ning 4 ; Diao, Jinling 1 ; Zhou, Zhiqiang 1 ; Zhu, Wentao 1 ;
作者机构： 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Yuan Mingyuan West Rd 2, Beijing 100193, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China
3.Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
4.Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Sch Life Sci, Beijing 100084, Peoples R China
关键词： Acetate; Bifidobacterium; Cyproconazole; Gut microbiota; Metabolomics analysis
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）
ISSN： 0048-9697
年卷期： 2024 年 912 卷
页码：
收录情况： SCI
摘要： The widespread use of cyproconazole (CPZ) enhances food security but may pose potential risks to non-target organisms. Therefore, we applied Multi-omics techniques to reveal the response of the intestinal barrier to CPZ exposure and explore whether the Bifidobacterium intervention experiment can repair the damage. First, we found that exposure to CPZ at environmentally relevant concentrations led to intestinal injury phenotype, significantly down-regulated intestinal protein gene expression, and up-regulated pro-inflammatory gene expression, further causing intestinal dysbacteriosis and metabolic disorders. In particular, by combining analysis of gut microbiota and metabolites, we noticed acetate, a key metabolite, which decreased sharply after exposure to high concentration of CPZ. Expectedly, after supplementing with Bifidobacterium (a core bacterium that produces acetate), we noticed that the acetate content was quickly restored. Further, we also verified that the increase in acetate content after Bifidobacterium supplementation at least partially promoted IL-22 secretion, which in turn stimulated the secretion of beta-defensins (zfbd-1, zfbd-2, zfbd-3), thereby repairing the intestinal damage. In conclusion, our work confirms the potential of Bifidobacterium to improve intestinal damage and metabolic dysbiosis caused by CPZ exposure. It provides directional recommendations for the application of probiotics to repair the toxicological risk of pesticide exposure.
- 相关文献
作者其他论文 更多>>
-
Integrated assessment of the spatial distribution, sources, degradation, and human risk of tetracyclines in honey in China
作者：Wang, Xinran;Luan, Yunxia;Tian, Sinuo;Li, Cheng;Wang, Xinran;Li, Yi;Zhou, Jinhui;Dong, Yiwei;Li, Yi;Zhou, Jinhui
关键词：Honey; Tetracyclines; Spatial distribution; Degradation patterns; Risk assessment
-
Multi-omics and gut microbiome: Unveiling the pathogenic mechanisms of early-life pesticide exposure
作者：Yue, Yifan;Sun, Xiaoxuan;Sun, Wei;Miao, Jiyan;Huang, Shiran;Diao, Jinling;Zhou, Zhiqiang;Zhu, Wentao;Tian, Sinuo;Yan, Sen;Zhu, Wentao
关键词：Exposure; Mechanism; Health effects; Pesticides; Microbiome
-
Bark transcriptome analyses reveals molecular mechanisms involved in tapping panel dryness occurrence and development in rubber tree (Hevea brasiliensis)
作者：Yue, Yifan;Deng, Zhi;Wang, Difei;Li, Dejun;Wang, Xuncheng;Xia, Zhihui;Li, Yao;Yin, Han;Yue, Yifan;Wang, Difei;Li, Dejun
关键词：Tapping panel dryness (TPD); Hevea brasiliensis; Molecular mechanisms; Transcriptome analyses; TPD-related genes
-
Veg-DenseCap: Dense Captioning Model for Vegetable Leaf Disease Images
作者：Sun, Wei;Wang, Chunshan;Gu, Jingqiu;Sun, Xiang;Sun, Wei;Wang, Chunshan;Gu, Jingqiu;Sun, Xiang;Sun, Wei;Wang, Chunshan;Gu, Jingqiu;Sun, Xiang;Sun, Wei;Wang, Chunshan;Li, Jiuxi;Liang, Fangfang
关键词：image captioning; disease detection; text generation; Faster R-CNN; attention mechanism
-
DFYOLOv5m-M2transformer: Interpretation of vegetable disease recognition results using image dense captioning techniques
作者：Sun, Wei;Wang, Chunshan;Wu, Huarui;Miao, Yisheng;Zhu, Huaji;Guo, Wang;Sun, Wei;Wang, Chunshan;Li, Jiuxi;Wu, Huarui;Miao, Yisheng;Zhu, Huaji;Guo, Wang;Wu, Huarui;Miao, Yisheng;Zhu, Huaji;Guo, Wang;Sun, Wei;Wang, Chunshan;Li, Jiuxi
关键词：Image captioning; Disease recognition; YOLOv5m; M2-Transformer; Two-stage; NWD
-
Fish school feeding behavior quantification using acoustic signal and improved Swin Transformer
作者：Zeng, Yuhao;Yang, Xinting;Zeng, Yuhao;Yang, Xinting;Pan, Liang;Zhu, Wentao;Wang, Dinghong;Zhao, Zhengxi;Liu, Jintao;Sun, Chuanheng;Zhou, Chao;Zeng, Yuhao;Yang, Xinting;Pan, Liang;Zhu, Wentao;Wang, Dinghong;Zhao, Zhengxi;Liu, Jintao;Sun, Chuanheng;Zhou, Chao;Zeng, Yuhao;Yang, Xinting;Pan, Liang;Zhu, Wentao;Wang, Dinghong;Zhao, Zhengxi;Liu, Jintao;Sun, Chuanheng;Zhou, Chao;Zhou, Chao
关键词：Aquaculture; Feeding acoustics recognition; Fish feeding behavior quantification; Improved Swin Transformer network; Deep learning
-
A Low-Altitude Remote Sensing Inspection Method on Rural Living Environments Based on a Modified YOLOv5s-ViT
作者：Wang, Chunshan;Sun, Wei;Teng, Guifa;Wang, Chunshan;Wu, Huarui;Zhao, Chunjiang;Wang, Chunshan;Sun, Wei;Teng, Guifa;Yang, Yingru;Du, Pengfei
关键词：Vision Transformer; attention mechanism; target detection; unmanned aerial vehicle (UAV); YOLOv5
