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Chronic ammonia toxicity disturbed energy homeostasis and damaged the hepatopancreas of swimming crab Portunus trituberculatus

文献类型： 外文期刊

作者： Zhang, Yueqi 1 ; Cao, Jianwei 1 ; Meng, Xianliang 3 ; Wang, Wenqi 2 ; Wang, Jinye 2 ; Wang, Fang 1 ; Lu, Yunliang 2 ;

作者机构： 1.Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao 266003, Peoples R China

2.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Aquat Genom, Minist Agr & Rural Affairs, Qingdao 266071, Peoples R China

关键词： Crustacean; Environmental stress; Tissue deformation; Metabolic demand; Recovery; P. trituberculatus

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：3.8 ）

ISSN： 2352-5134

年卷期： 2023 年 32 卷

页码：

收录情况： SCI

摘要： Ammonia is toxic to aquatic animals and its chronic effects on the swimming crab Portunus trituberculatus is still not fully understood. Therefore, we conducted this study to detect the responses of energy metabolism of crabs to chronic high environmental ammonia (HEA) exposure by exposing them to HEA (5 and 15 mg center dot L-1) for 15 d and subsequently recovering in natural seawater for 7 d. Then we analyzed the glucose and lactate content, ATPases activities and the expression of the genes involved in energy homeostasis. Besides, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), alkaline phosphatase (AKP) activity and histological changes were assayed to determine the HEA-induced hepatopancreas damage. Results showed a HEA dose- and exposure time-dependent mortality and hepatopancreas damage. This was accompanied by a loss of energy homeostasis as indicated by the significant increase of AMP/ATP ratio and genes expression involved in AMPK pathway (P < 0.05). While indices such as HMGCR expression, glucose content and ion related ATPases demonstrated the energy dishomeostasis might be related with the inhibitory effect of chronic HEA on energy regulatory capacity especially when HEA approached 15 mg center dot L-1. In summary, chronic HEA can seriously damage hepatopancreas structure and function of energy metabolism in P. trituberculatus, and this deleterious effect could even not be completely repaired in a short recovery time.

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