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Protective Effects of Cereal-Based Fermented Beverages Against 5-Fluorouracil-Induced Intestinal Damage in Mice

文献类型： 外文期刊

作者： Qin, Dongze 1 ; Fu, Wenhui 1 ; Sun, Yi 1 ; Zhao, Lingda 1 ; Liu, Haiwei 1 ; Fan, Dancai 1 ; Tan, Dongfei 2 ; Ji, Xuemeng 1 ; Wang, Shuo 1 ;

作者机构： 1.Nankai Univ, Sch Med, Tianjin Key Lab Food Sci & Hlth, Tianjin 300071, Peoples R China

2.Tianjin Acad Agr Sci TAAS, Inst Agroprod Safety & Nutr, Tianjin 300192, Peoples R China

关键词： cereal; fermentation; 5-flourouracil; intestinal mucositis; oxidative stress

期刊名称：NUTRIENTS （ 影响因子：5.0； 五年影响因子：6.0 ）

ISSN：

年卷期： 2024 年 16 卷 24 期

页码：

收录情况： SCI

摘要： Background: 5-Fluorouracil (5-FU) is a common chemotherapeutic medication used to treat cancer. However, the intestinal tract may sustain oxidative damage as a result. Objectives: The purpose of this study was to clarify the underlying molecular mechanisms and examine the preventive benefits of cereal-based fermented drinks (CFBs) against intestinal injury in mice caused by 5-FU. Methods: The mice were injected intraperitoneally with 5-FU to induce intestinal mucosal and treated with CFB. The factors for intestinal barrier integrity, oxidative stress and inflammation were measured. Results: The findings demonstrated that CFBs had high levels of polyphenol, flavonoids, and peptides and had in vitro high free radical scavenging capacity. Furthermore, CFBs effectively ameliorated 5-FU-induced intestinal epithelium damage, characterized by increasing intestinal tight junctions and reducing apoptosis in intestinal cells. These protective effects may attribute to the increased activity of antioxidant-related enzymes (SOD, CAT, and GSH) as well as decreased amounts of inflammatory and oxidative damage markers (IL-1 beta, TNF-alpha, and MDA) in the intestinal tract. Conclusions: Overall, these results show that CFBs can mitigate intestinal damage caused by 5-FU by reducing oxidative stress, suggesting the potential utility of CFBs for therapeutic treatment against intestinal mucositis.

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