Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)
文献类型： 外文期刊
作者： Huang, Peng 1 ; Cao, Liping 1 ; Du, Jinliang 1 ; Guo, Yiqing 1 ; Li, Quanjie 2 ; Sun, Yi 2 ; Zhu, Haojun 2 ; Xu, Gangchun 1 ; Gao, Jiancao 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China
关键词： NPs; PFAS; Aquatic crustacean; Multi-omics; Combined toxicity
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）
ISSN： 0304-3894
年卷期： 2025 年 488 卷
页码：
收录情况： SCI
摘要： Nanoplastics (NPs), the final form of degraded microplastics in the environment, can adsorb PFOA (an emerging organic pollutant in recent years) in several ways. Current research on these has focused on bony fishes and mollusks, however, the combined toxicity of PFOA and NPs remains unknown in Eriocheir sinensis. Therefore, the effects of single or combined exposure to PFOA and NPs were investigated. The results showed that NPs aggravated PFOA exposure-induced oxidative stress, serum lipid disorders, immune responses, and morphological damage. DEGs altered by NPs-PFOA exposure were predominantly enriched in GO terms for cell lumen, and organelle structure, and KEGG terms for spliceosome and endocrine disorders-related diseases. Notably, the apoptotic pathway plays a central role enriched under different exposure modes. PFOA or NPs-PFOA exposure disrupted the levels of lipids molecules-related metabolites by mediating the glycerophospholipid pathway, and the NPs mediated the ferroptosis pathway to exacerbate PFOA-induced metabolic toxicity. In addition, NPs exacerbated the inflammatory response and metabolic imbalance by mediating Fusobacterium ulcerans in the intestinal. In conclusion, this study provides a valuable reference for the characterization of NPs-PFOA combined pollution and a scientific basis for the development of environmental protection policies and pollution management strategies.
- 相关文献
作者其他论文 更多>>
-
Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure
作者：Zheng, Yao;Li, Jiajia;Gao, Jiancao;Hu, Jiawen;Sun, Yi;Zhu, Haojun;Xu, Gangchun;Zheng, Yao;Jin, Wei;Xu, Gangchun
关键词：Liver; Endoplasmic reticulum; MAPK signaling pathway; Acute exposure
-
Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via Bursicon in the Cerebral Ganglion of Chinese Mitten Crab Eriocheir sinensis Under Alkaline Stress
作者：Wang, Meiyao;Xu, Gangchun;Tang, Yongkai;Wang, Meiyao;Xu, Gangchun;Tang, Yongkai;Zhou, Jun;Ge, Jiachun
关键词：
Eriocheir sinensis ; cerebral ganglia; alkalinity stress;bursicon ; signal transduction -
Probiotic Supplementation Improves Lipid Metabolism Disorders and Immune Suppression Induced by High-Fat Diets in Coilia nasus Liver
作者：Gao, Jun;Sun, Yi;Xu, Gangchun;Mang, Qi
关键词：
Coilia nasus ; 4D-DIA proteomics; probiotics supplementation; high-fat diet; lipid metabolism; metabolism disorder -
Microbial-algal symbiotic system drives reconstruction of nitrogen, phosphorus, and methane cycles for purification of pollutants in aquaculture water
作者：Gao, Jun;Mang, Qi;Li, Quanjie;Sun, Yi;Xu, Gangchun;Mang, Qi
关键词：Bacillus subtilis; Chlorella pyrenoidosa; Cross feeding; Environmental microorganisms; Element cycles
-
Characteristics of Intestinal Microbiota and Host Gene Regulation in Coilia nasus Responding to Stress
作者：Gao, Jun;Zhu, Haojun;Gao, Jiancao;Xu, Gangchun
关键词：stress response; intestinal microbiota; oxidative stress; ferroptosis;
Coilia nasus -
Endocytosis, endoplasmic reticulum, actin cytoskeleton affected in tilapia liver under polystyrene microplastics and BDE153 acute co-exposure
作者：Zheng, Yao;Li, Jiajia;Zhu, Haojun;Hu, Jiawen;Sun, Yi;Xu, Gangchun
关键词：Liver; Endocytosis; Protein processing in endoplasmic reticulum; Regulation of actin cytoskeleton; Nano-polystyrene microplastics and BDE153 co- exposure
-
Short-Chain Fatty Acids (SCFAs) Modulate the Hepatic Glucose and Lipid Metabolism of Coilia nasus via the FFAR/AMPK Signaling Pathway In Vitro
作者：Gao, Jun;Sun, Yi;Xu, Gangchun;Mang, Qi
关键词：
Coilia nasus ; SCFAs; FFAR/AMPK; high glucose; high lipid
