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Long-lasting effects of lipopolysaccharide on the reproduction and splenic transcriptome of hens and their offspring

文献类型： 外文期刊

作者： Liu, Lei 2 ; Wang, Di 2 ; Li, Xingzheng 3 ; Adetula, Adeyinka Abiola 3 ; Khan, Adnan 3 ; Zhang, Bing 1 ; Liu, Huagui 1 ; Yu, Ying 2 ; Chu, Qin 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100094, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Beijing 100193, Peoples R China

3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Genom Anal Lab Min Agr & Rural Affairs, Guangdong Lab Lingnan Modern Agr,Shenzhen Branch, Shenzhen 518124, Guangdong, Peoples R China

4.China Agr Univ, Coll Anim Sci & Technol, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

5.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, 9 Shuguanghuayuan Middle Rd, Beijing 100089, Peoples R China; China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Beijing 100193, Peoples R China

关键词： Laying hens; LPS maternal stimulation; Immunity; Egg-laying rate; Transcriptome; Long-lasting effect

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：7.129； 五年影响因子：7.284 ）

ISSN： 0147-6513

年卷期： 2022 年 237 卷

页码：

收录情况： SCI

摘要： Lipopolysaccharide (LPS) is ubiquitous in the environment and is released after the death of gram-negative bacteria, which may be related to inflammation and immunosuppression. However, its impact on the reproduction of animals and their offspring, especially the underlying mechanism need further elucidation. Here, we used laying hens as a model organism to investigate the effects of maternal exposure to LPS (LPS maternal stimulation) on animal and their offspring's immunity and reproductive performance, as well as the regulatory role of the transcriptome. We found that the LPS maternal stimulation could reduce the egg-laying rate of hens and their offspring, especially during the early and late laying stages. The transcriptome study of the spleen in F0, F1 and F2 generations showed that the maternal stimulation of the LPS affects the patterns of gene expression in laying hens, and this change has a long-lasting effect. Further analysis of DEGs and their enrichment pathways found that the LPS maternal stimulation mainly affects the reproduction and immunity of laying hens and their offspring. The DEGs such as AVD, HPS5, CATHL2, S100A12, EXFABP, RSFR, LY86, PKD4, XCL1, FOS, TREM2 and MST1 may play an essential role in the regulation of the immunity and egg-laying rate of hens. Furthermore, the MMR1L3, C3, F13A1, LY86 and GDPD2 genes with heritable effects are highly correlated with the egg-laying rate, may have an important reference value for further research. Our study reveals the profound implications of LPS exposure on immunity and reproduction of offspring, elaborating the impact of immune alteration on the egg-laying rate, emphasizing the regulatory role of intergenerational transmission of the transcriptome, implying that the environment parents being exposed to has an important impact on offspring.

  • 相关文献

[1]Long-lasting effects of lipopolysaccharide on the reproduction and splenic transcriptome of hens and their offspring. Zhang, Bing,Liu, Huagui,Chu, Qin,Liu, Lei,Wang, Di,Yu, Ying,Liu, Lei,Wang, Di,Li, Xingzheng,Adetula, Adeyinka Abiola,Khan, Adnan,Yu, Ying,Yu, Ying,Chu, Qin. 2022

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