Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus
文献类型： 外文期刊
作者： Sun, Ju 1 ; Zheng, Tianyi 2 ; Jia, Mingjun 1 ; Wang, Yanjun 2 ; Yang, Jingru 2 ; Liu, Yun 1 ; Yang, Pengyun 1 ; Xie, Yufeng 2 ; Sun, Honglei 3 ; Tong, Qi 3 ; Li, Jiaming 2 ; Yang, Jing 2 ; Fu, Guanghua 4 ; Shi, Yi 2 ; Qi, Jianxun 2 ; Liu, Wenjun 2 ; Liu, Jinhua 3 ; Tian, Wen-xia 1 ; Gao, George F. 2 ; Bi, Yuhai 1 ;
作者机构： 1.Shanxi Agr Univ, Coll Vet Med, Jinzhong 030801, Peoples R China
2.Chinese Acad Sci, CAS TWAS Ctr Excellence Emerging Infect Dis CEEID, CAS Key Lab Pathogen Microbiol & Immunol, Ctr Influenza Res & Early Warning CASCIRE,Inst Mi, Beijing 100101, Peoples R China
3.China Agr Univ, Coll Vet Med, Natl Key Lab Vet Publ Hlth & Safety, Key Lab Anim Epidemiol,Minist Agr & Rural Affairs, Beijing 100193, Peoples R China
4.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Zhejiang Univ, D H Chen Sch Universal Hlth, Hangzhou 310058, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2024 年 15 卷 1 期
页码：
收录情况： SCI
摘要： The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype. The authors identify one emerging H2N2 AIV, reveal the molecular basis of human-type receptor binding of the H2N2 AIV and pandemic strains, and evaluate the public risk of H2N2 AIV by its infection, transmission and mammalian-adaptation features.
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