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The additional PRC2 subunit and Sin3 histone deacetylase complex are required for the normal distribution of H3K27me3 occupancy and transcriptional silencing in Magnaporthe oryzae

文献类型： 外文期刊

作者： Lin, Chuyu 1 ; Wu, Zhongling 1 ; Shi, Huanbin 3 ; Yu, Jinwei 1 ; Xu, Mengting 1 ; Lin, Fucheng 1 ; Kou, Yanjun 3 ; Tao, Zeng 1 ;

作者机构： 1.Zhejiang Univ, Inst Biotechnol, Key Lab Mol Biol Crop Pathogens & Insects, Minist Agr, Hangzhou 310058, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 311400, Peoples R China

3.China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou 310021, Peoples R China

关键词： additional subunit; histone deacetylase complex; Magnaporthe oryzae; polycomb repressive complex

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.323； 五年影响因子：10.768 ）

ISSN： 0028-646X

年卷期：

页码：

收录情况： SCI

摘要： Development in higher organisms requires proper gene silencing, partially achieved through trimethylation of lysine 27 on histone H3 (H3K27me3). However, how the normal distribution of this modification is established and maintained and how it affects gene expression remains unclear, especially in fungi. Polycomb repressive complex 2 (PRC2) catalyses H3K27me3 to assemble transcriptionally repressed facultative heterochromatin and is crucial in animals, plants, and fungi. Here, we report on the critical role of an additional PRC2 subunit in the normal distribution of H3K27me3 occupancy and the stable maintenance of gene repression in the rice fungal pathogen Magnaporthe oryzae. P55, identified as an additional PRC2 subunit, is physically associated with core subunits of PRC2 and is required for a complete level of H3K27me3 modification. Loss of P55 caused severe global defects in the normal distribution of H3K27me3 and transcriptional reprogramming on the H3K27me3-occupied genes. Furthermore, we found that the Sin3 histone deacetylase complex was required to sustain H3K27me3 occupancy and stably maintain gene repression by directly interacting with P55. Our results revealed a novel mechanism by which P55 and Sin3 participate in the normal distribution of facultative heterochromatic modifications and the stable maintenance of gene repression in eukaryotes.

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[1]The additional PRC2 subunit and Sin3 histone deacetylase complex are required for the normal distribution of H3K27me3 occupancy and transcriptional silencing in Magnaporthe oryzae. Lin, Chuyu,Wu, Zhongling,Yu, Jinwei,Xu, Mengting,Lin, Fucheng,Tao, Zeng,Lin, Chuyu,Lin, Fucheng,Shi, Huanbin,Kou, Yanjun.

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