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Characterization and expression profiling of serine protease inhibitors in the yellow mealworm Tenebrio molitor

文献类型： 外文期刊

作者： Li, Guang-Ya 1 ; Yang, Lin 1 ; Xiao, Kai-Ran 1 ; Song, Qi-Sheng 2 ; Stanley, David 3 ; Wei, Shu-Jun 1 ; Zhu, Jia-Ying 1 ;

作者机构： 1.Southwest Forestry Univ, Key Lab Forest Disaster Warning & Control Yunnan, Kunming, Yunnan, Peoples R China

2.Univ Missouri, Div Plant Sci & Technol, Columbia, MO USA

3.ARS, USDA, Biol Control Insects Res Lab, Columbia, MO USA

4.Beijing Acad Agr & Forestry Sci, Inst Plant Protect, Beijing, Peoples R China

5.Southwest Forestry Univ, Key Lab Forest Resources Conservat & Utilizat Sou, Minist Educ, Kunming, Yunnan, Peoples R China

关键词： expression profile; serine protease inhibitor; serpin; Tenebrio molitor

期刊名称：ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：2.454； 五年影响因子：2.11 ）

ISSN： 0739-4462

年卷期：

页码：

收录情况： SCI

摘要： Serine protease inhibitors (SPIs) act in diverse biological processes in insects such as immunity, development, and digestion by preventing the unwanted proteolysis. So far, the repertoire of genes encoding SPIs has been identified from few insect species. In this study, 62 SPI genes were identified from the genome of the yellow mealworm, Tenebrio molitor. According to their modes of action, they were classified into three families, serpin (26), canonical SPI (31), and alpha-macroglobulins (A2M) (5). These SPIs feature eight domains including serpin, Kazal, TIL, Kunitz, WAP, Antistasin, pacifastin, and A2M. In total, 39 SPIs contain a single SPI domain, while the others encode at least two inhibitor units. Based on the amino acids in the cleaved reactive sites, the abilities of these SPIs to inhibit trypsin, chymotrypsin, or elastase-like enzymes are predicted. The expression profiling based on the RNA-seq data showed that these genes displayed stage-specific expression patterns during development, suggesting to us their significance in development. Some of the SPI genes were exclusively expressed in particular tissues such as hemocyte, fat body, gut, ovary, and testis, which may be involved in biological processes specific to the indicated tissues. These findings provide necessary information for further investigation of insect SPIs.

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