Brain Injury Induced by Mercury in Common Carp: Novel Insight from Transcriptome Analysis
文献类型： 外文期刊
作者： Zhang, Yue 1 ; Lu, Yuting 1 ; Zhang, Peijun 3 ; Shang, Xinchi 4 ; Li, Yuehong 1 ;
作者机构： 1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130118, Peoples R China
2.Jilin Agr Univ, Minist Educ Lab Anim Prod & Qual Secur, Changchun 130118, Peoples R China
3.Hlth Monitoring & Inspect Ctr Jilin Prov, Changchun 130062, Peoples R China
4.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Rd 43 Songfa, Harbin 150070, Peoples R China
5.Key Lab Cold Water Fish Germplasm Resources & Mul, Harbin 150070, Heilongjiang, Peoples R China
关键词： Mercury chloride; Ion channels; Brain; Ferroptosis
期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：4.081； 五年影响因子：3.755 ）
ISSN： 0163-4984
年卷期：
页码：
收录情况： SCI
摘要： Mercury is a heavy metal which causes irreversible toxicity to fish and is detected in aquatic environment around the world. We aimed to explore the relative mechanism of mercury exposure on the brain injury. In this study, high-throughput sequencing RNA-Seq technology was carried out to analyze the changes of gene expression of brain tissues exposed to mercury. A large number of differentially expressed genes were identified. And 366 genes were up-regulated and 688 genes were down-regulated. Gene Ontology (GO) functional enrichment analysis showed that DNA-templated and transport were highly enriched in the biological process. Membrane, nucleus, and cytoplasm were highly enriched in the cellular component, and metal ion binding and DNA binding were highly enriched in molecular function. The differential genes were enriched in ferroptosis, necroptosis, calcium signaling pathway, and ion channels. Real-time quantitative reverse transcription PCR (qRT-PCR) results demonstrated the selected genes exhibited the same trends with the RNA-Seq results, which indicates the transcriptome sequencing data is reliable. Our results may provide an insightful view for the toxic effects of mercury on brain injury of common carp.
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