Integrated physiologic and proteomic analysis of Stropharia rugosoannulata mycelia in response to Cd stress
文献类型： 外文期刊
作者： Dong, Qin 1 ; Chen, Mingjie 1 ; Zhang, Yaru 1 ; Song, Panpan 1 ; Yang, Huanling 1 ; Zhao, Yan 1 ; Yu, Changxia 1 ; Zha, Lei 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China
2.Shanghai Key Lab Agr Genet & Breeding, Shanghai 201403, Peoples R China
3.Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China
关键词： Stropharia rugosoannulata; Cadmium (Cd); Differentially expressed proteins (DEPs); Antioxidant system; Energy metabolism
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：14.224； 五年影响因子：12.984 ）
ISSN： 0304-3894
年卷期： 2023 年 441 卷
页码：
收录情况： SCI
摘要： Soil Cd pollution seriously threatens environment and human health. Due to its ability to absorb and accumulate Cd in mycelia, Stropharia rugosoannulata could be a potential candidate for bioremediation of Cd-contaminated soils; however, the response mechanism of mycelia to Cd stress is still unclear. In this study, the physiologic and proteomic differences of S. rugosoannulata mycelia under 0.2 mg/L (low) and 2 mg/L (high) Cd stress were investigated. The results showed that Cd accumulation and mycelial growth inhibition exhibited a concentration -depended trend. Analysis of antioxidant system indicated that SOD, GR, GSH, GSSG and ASA played key roles in resisting the toxic effects of Cd. Via proteome analysis, 24 and 267 differentially expressed proteins (DEPs) were observed under low and high Cd stress, respectively. GO and KEGG analysis found that the mycelial growth inhibition might due to the down-regulation of some DEPs involved in "valine, leucine and isoleucine biosyn-thesis " and "tyrosine metabolism "; the certain tolerance to high Cd stress might attribute to the regulation of DEPs referred to energy metabolism and antioxidant system-related pathways, maintaining cellular energy homeostasis and removing ROS. These results provide a theoretical basis for further elucidation of response mechanisms in S. rugosoannulata to Cd stress.
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