ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation
文献类型： 外文期刊
作者： Xu, Jing 1 ; Zhou, Lian 3 ; Chen, Kaixin 1 ; Huang, Runsen 1 ; Niu, Baixiao 4 ; Ye, Juanying 5 ; Ma, Hong 6 ; Copenhaver, Gregory P. 7 ; Wang, Yingxiang 1 ;
作者机构： 1.South China Agr Univ, Coll Life Sci, Guangdong Basic Res Ctr Excellence Precise Breedin, Guangdong Lab Lingnan Modern Agr,Guangdong Prov Ke, Guangzhou 510642, Peoples R China
2.Shaoguan Univ, Sch Biol & Agr, Shaoguan 512005, Peoples R China
3.Guangdong Acad Agr Sci, Rice Res Inst, Guangzhou 510640, Peoples R China
4.Yangzhou Univ, Minist Educ, Key Lab Plant Funct Genom, Jiangsu Prov Key Lab Crop Genet & Physiol,Coinnova, Yangzhou 225009, Peoples R China
5.Chinese Acad Sci, Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Plant Sci,Natl Key Lab Plan, Shanghai 200032, Peoples R China
6.Penn State Univ, Huck Inst Life Sci, Eberly Coll Sci, Dept Biol, University Pk, PA 16802 USA
7.Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA
8.Univ North Carolina Chapel Hill, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA
9.Univ North Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA
期刊名称：PLANT CELL （ 影响因子：11.6； 五年影响因子：12.1 ）
ISSN： 1040-4651
年卷期： 2025 年 37 卷 6 期
页码：
收录情况： SCI
摘要： Faithful chromosome segregation is essential for both mitotic and meiotic cell division. The anaphase-promoting complex/cyclosome (APC/C) and its coactivators are required for meiotic chromosome segregation, but their potential targets and regulatory mechanisms remain unclear in plants. Here, we performed a ubiquitinome analysis and show that Arabidopsis thaliana Aurora 1 (AUR1) is over-ubiquitinated at lysine 102 in the coactivator Cell Division Cycle 20.1 (cdc20.1) mutants and that AUR1 overexpression can partially rescue the cdc20.1 meiotic defect. We also demonstrate that APC/C ubiquitinates AUR1, leading to its degradation through the 26S proteasome pathway. Moreover, the APC/C subunit and coactivators Cell Cycle Switch 52 A2/B (CCS52A2/B) and CDC20.1 interact with AUR1 both in vitro and in vivo. Intriguingly, CCS52A2/B promotes AUR1 ubiquitination and degradation, while CDC20.1 prevents AUR1 degradation. Consistent with this finding, AUR1 levels are lower in cdc20.1 and higher in ccs52 mutants relative to Col-0, and mutation of CCS52A2/B causes defects in meiotic spindle assembly and homologous chromosome segregation. Genetic analyses demonstrate that Arabidopsis anaphase-promoting complex/cyclosome subunit 8 (APC8), CDC20.1, CCS52 and AUR1 act in the same pathway to control meiotic spindle assembly and homologous chromosome segregation. Thus, this work provides mechanistic insight into the role of APC/C coactivators in regulating AUR1 homeostasis during meiosis in plants. The ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators CDC20.1 and CCS52s play distinct roles in maintaining AURORA 1 kinase homeostasis during meiotic chromosome segregation in Arabidopsis.
- 相关文献
作者其他论文 更多>>
-
Natural variation in CTF1 conferring cold tolerance at the flowering stage in rice
作者：Dong, Jingfang;Zhang, Shaohong;Hu, Haifei;Wang, Jian;Li, Risheng;Wu, Jing;Chen, Jiansong;Zhou, Lian;Ma, Yamei;Li, Wenhui;Nie, Shuai;Liu, Bin;Zhao, Junliang;Yang, Tifeng;Li, Risheng;Wu, Jing;Wang, Shaokui;Zhang, Guiquan
关键词：cold tolerance; QTL; single segment substitution line; haplotype analysis; functional site; rice
-
Linkage and association mapping in multi-parental populations reveal the genetic basis of carotenoid variation in maize kernels
作者：Yin, Pengfei;Fu, Xiuyi;Feng, Haiying;Yang, Yanyan;Xu, Jing;Zhang, Xuan;Wang, Min;Ji, Shenghui;Zhao, Binghao;Fang, Hui;Du, Xiaoxia;Li, Yaru;Hu, Shuting;Li, Kun;Xu, Shutu;Li, Zhigang;Li, Jiansheng;Yang, Xiaohong;Yin, Pengfei;Fu, Xiuyi;Feng, Haiying;Yang, Yanyan;Xu, Jing;Zhang, Xuan;Wang, Min;Ji, Shenghui;Zhao, Binghao;Fang, Hui;Du, Xiaoxia;Li, Yaru;Hu, Shuting;Li, Kun;Xu, Shutu;Li, Zhigang;Li, Jiansheng;Yang, Xiaohong;Fu, Xiuyi;Wang, Yuandong;Liu, Fang;Li, Jiansheng;Yang, Xiaohong;Xiao, Yingni;Yang, Xiaohong
关键词：Carotenoids; Linkage analysis; Association mapping; Plastid terminal oxidase
-
Pangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice
作者：Wang, Jian;Hu, Haifei;Zhang, Shaohong;Yang, Wu;Dong, Jingfang;Yang, Tifeng;Ma, Yamei;Zhou, Lian;Chen, Jiansong;Nie, Shuai;Liu, Chuanguang;Liu, Bin;Zhao, Junliang;Wang, Jian;Hu, Haifei;Zhang, Shaohong;Yang, Wu;Dong, Jingfang;Yang, Tifeng;Ma, Yamei;Zhou, Lian;Chen, Jiansong;Nie, Shuai;Liu, Chuanguang;Liu, Bin;Zhao, Junliang;Wang, Jian;Hu, Haifei;Zhang, Shaohong;Yang, Wu;Dong, Jingfang;Yang, Tifeng;Ma, Yamei;Zhou, Lian;Chen, Jiansong;Nie, Shuai;Liu, Chuanguang;Liu, Bin;Zhao, Junliang;Wang, Jian;Hu, Haifei;Zhang, Shaohong;Yang, Wu;Dong, Jingfang;Yang, Tifeng;Ma, Yamei;Zhou, Lian;Chen, Jiansong;Nie, Shuai;Liu, Chuanguang;Liu, Bin;Zhao, Junliang;Zhu, Xiaoyuan;Yang, Jianyuan;Zhu, Xiaoyuan;Yang, Jianyuan;Jiang, Xianya;Ning, Yuese
关键词：Rice; Blast resistance; Pangenome-wide association study; Transcriptomic analysis; Candidate genes
-
GWAS and Transcriptomic Analysis Identify OsRING315 as a New Candidate Gene Controlling Amylose Content and Gel Consistency in Rice
作者：Nie, Shuai;Chen, Luo;Zheng, Minhua;Dong, Jingfang;Ma, Yamei;Zhou, Lian;Wang, Jian;Chen, Jiansong;Hu, Haifei;Yang, Tifeng;Zhao, Junliang;Zhang, Shaohong;Yang, Wu
关键词：Rice; Cooking quality; Genome-wide association study; Quantitative trait loci (QTL); Candidate gene
-
The Function of SD1 on Shoot Length and its Pyramiding Effect on Shoot Length and Plant Height in Rice (Oryza sativa L.)
作者：Dong, Jingfang;Ma, Yamei;Hu, Haifei;Wang, Jian;Yang, Wu;Fu, Hua;Zhang, Longting;Chen, Jiansong;Zhou, Lian;Li, Wenhui;Nie, Shuai;Zhao, Junliang;Liu, Bin;Yang, Tifeng;Zhang, Shaohong;Zhang, Longting;Liu, Ziqiang
关键词：Shoot Length; Plant Height; Causal gene; Allele Mining; Pyramiding Effect; Rice
-
A soybean bZIP transcription factor is involved in submergence resistance
作者：Lin, Yanhui;Xu, Jing;Li, Yapeng;Zhu, Honglin;Tang, Liqiong;Wang, Xiaoning;Li, Yapeng;Wang, Xiaoning;Huo, Xing;Yu, Yongmei
关键词：GmbZIP71-4; Transcription factor; Abiotic stress; Submergence resistant; ABA
-
A Novel Function of GW5 on Controlling the Early Growth Vigor and its Haplotype Effect on Shoot Dry Weight and Grain Size in Rice (Oryza sativa L.)
作者：Yang, Tifeng;Dong, Jingfang;Xiong, Xijuan;Zhang, Longting;Wang, Jian;Hu, Haifei;Zhou, Lian;Yang, Wu;Ma, Yamei;Fu, Hua;Chen, Jiansong;Li, Wenhui;Nie, Shuai;Liu, Bin;Wang, Feng;Zhao, Junliang;Zhang, Shaohong;Xiong, Xijuan;Zhang, Longting;Liu, Ziqiang
关键词：Genome-wide association analysis (GWAS); Quantitative trait loci (QTL); Shoot dry weight; Causal gene; Rice
