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A dual-response fluorescent probe to reveal the role of ferroptosis in drug-induced liver injury

文献类型： 外文期刊

作者： Liu, Jianfei 1 ; Li, Changyi 1 ; Sun, Junmin 1 ; Zhang, Di 2 ; Yang, Xiaopeng 3 ; Ye, Yong 1 ; Zhao, Yufen 1 ;

作者机构： 1.Zhengzhou Univ, Coll Chem, Zhengzhou 450051, Peoples R China

2.Henan Acad Agr Sci, Inst Qual & Safety Agroprod, Henan Key Lab Grain Qual & Safety Testing, Zhengzhou 450002, Peoples R China

3.Henan Agr Univ, Coll Tobacco Sci, Zhengzhou 450046, Peoples R China

关键词： Fluorescent probe; HNO; Viscosity; Ferroptosis; DILI

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.3； 五年影响因子：13.2 ）

ISSN： 1385-8947

年卷期： 2024 年 495 卷

页码：

收录情况： SCI

摘要： Drug-induced liver injury (DILI) has already been recognized as a formidable obstacle in global health issues. Despite the proposed common cellular death types in DILI, exploration of alternative mechanisms such as ferroptosis for prevention and therapy remains limited. Visualization of the role of ferroptosis in DILI holds profound promise in advancing diagnostic and therapeutic strategies for DILI. To address this, herein, a unique multi-functional fluorescent probe, VIS-HNO, was elaborately built up and endowed with the extraordinary performance of excellent selectivity and high sensitivity toward HNO and viscosity. Employing the probe VISHNO with the confocal fluorescence imaging, the up-regulations of HNO and viscosity in the process of DILI and ferroptosis were disclosed. Then the remediation of DILI was achieved by VIS-HNO under the treatment of ferrostatin1 (Fer-1), indicating its therapeutic value for DILI. In addition, taking into account the significance of HNO in determining the role of ferroptosis in DILI, the pathway of HNO production in DILI was further explored, which presented essential insights into the role of ferroptosis in DILI. Overall, these findings demonstrated that VIS-HNO may be a potent tool to aid in diagnosing ferroptosis and DILI, more importantly, to understand the role of ferroptosis in DILI by evaluating HNO and viscosity level, which will facilitate the exploration of unique strategies for DILI treatment.

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