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Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells

文献类型： 外文期刊

作者： Li, Puwang 1 ; Wang, Yichao 1 ; Zeng, Fanbo 3 ; Chen, Lijue 3 ; Peng, Zheng 2 ; Kong, Ling Xue 1 ;

作者机构： 1.Deakin Univ, Ctr Mat & Fiber Innovat, Geelong, Vic 3217, Australia

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

3.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Peoples R China

关键词： Cell uptake;Chemical modification;Chitosan;Folate;HT-29 cells

期刊名称：CARBOHYDRATE RESEARCH （ 影响因子：2.104； 五年影响因子：2.192 ）

ISSN：

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收录情况： SCI

摘要： Folate-chitosan (FA-CS) conjugates synthesized by coupling FA with CS render new and improved functions because the original properties of CS are maintained and the targeting ligand of FA is incorporated. In this work, FA-CS conjugates were synthesized based on chemical linking of carboxylic group of FA with amino group of CS as confirmed by Fourier transform spectroscopy (FTIR) and nuclear magnetic resonance (~1H NMR). FA-CS conjugates displayed less crystal nature when compared to CS. The FA-CS nanoparticles (NPs) were prepared by crosslinking FA-CS conjugates with sodium tripolyphosphate (STPP). Positively charged FA-CS nanoparticles were spherical in shape with a particle size of about 100 nm. Cellular uptake of CS or FA-CS nanoparticles was assayed by fluorescent microscopy using calcein as fluorescent marker in colon cancer cells (HT-29). The FA-CS nanoparticles exhibited improved uptake of HT-29 and could become a potential targeted drug delivery system for colorectal cancer.

  • 相关文献

[1]Development of Ligand Incorporated Chitosan Nanoparticles for the Selective Delivery of 5-Fluorouracil to Colon. Li, Puwang,She, F. H.,Kong, L. X.,Li, Puwang,Li, Puwang,Peng, Zheng. 2011

[2]Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization. Zhou, Min,Li, Puwang,Wang, Guang,Yang, Ziming,Peng, Zheng,Kong, Lingxue. 2012

[3]Synthesis and characterization of chitosan quaternary ammonium salt and its application as drug carrier for ribavirin. Li, Si-Dong,Quan, Wei-Yan,Yang, Lei,Dong, Jing-Jing,Li, Pu-Wang,Yang, Zi-Ming,Peng, Zheng,Yang, Xi-Hong.

[4]Preparation of a Xanthine Sensor Based on the Immobilization of Xanthine Oxidase on a Chitosan Modified Electrode by Cross-linking. Liu Yuge,Li Weiming,Wei Changbin,Lu Lingling. 2012

[5]Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery. Wang, Yichao,Li, Puwang,Kong, Lingxue,Li, Puwang. 2013

[6]Soybean oil-chitosan emulsion affects internal quality and shelf-life of eggs stored at 25 and 4 degrees C. Wardy, Wisdom,Torrico, Damir D.,Zhang, Xiumei,Xu, Zhimin,Prinyawiwatkul, Witoon,Herrera Corredor, Jose A.,No, Hong Kyoon,Zhang, Xiumei. 2013

[7]Preparation and Characterization of Novel Chitosan-Based Microcapsule Containing Patchouli Oil. Yang, Ziming,Huang, Maofang,Peng, Zheng,Han, Guangtao,Li, Puwang,Yang, Ziming,Pang, Yuxin,Kong, Lingxue. 2013

[8]Preparation and Mechanical Properties of Prevulcanized Natural Rubber Latex/Chitosan/Poly (3-hydroxybutyrate) Blends. Lu, Guang,Yu, Heping,Wang, Yongzhou,Luo, Yongyue,Zeng, Zongqiang. 2015

[9]Preparation and Properties of Interpenetrating Polymer Network Films from Prevulcanized Natural Rubber Latex/Chitosan Blends. Lu, Guang,Yu, Heping,Zeng, Zongqiang,Luo, Yongyue. 2012

[10]Formulation of vanillin cross-linked chitosan nanoparticles and its characterization. Wang, Guang,Li, Puwang,Peng, Zheng,Huang, Maofang,Kong, Lingxue. 2011

[11]Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer. Wang, Yichao,Wang, Yichao,Li, Puwang,Thao Truong-Dinh Tran,Zhang, Juan,Kong, Lingxue,Li, Puwang,Thao Truong-Dinh Tran. 2016

[12]Preparation and evaluation of chitosan/alginate porous microspheres/Bletilla striata polysaccharide composite hemostatic sponges. Wang, Chao,Luo, Wenfeng,Ao, Ningjian,Wang, Chao,Li, Puwang,Yang, Ziming,Liu, Yangyang,Li, Sidong,Hu, Zhang. 2017

[13]Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells. Li, Pu-Wang,Wang, Guang,Yang, Zi-Ming,Peng, Zheng,Wang, Qing-Huang,Duan, Wei,Kong, Ling-Xue,Wang, Qing-Huang.

[14]Effect of chitosan/nano-silica coating on the physicochemical characteristics of longan fruit under ambient temperature. Shi, Shengyou,Wang, Wei,Liu, Liqin,Wei, Yongzan,Li, Weicai,Wang, Wei,Wu, Shijia.

[15]Thermal degradation of hydroxypropyl trimethyl ammonium chloride chitosan-Cd complexes. Li, Si-Dong,Yang, Xi-Hong,Yang, Lei,Li, Si-Dong,Li, Pu-Wang,Yang, Zi-Ming,Dong, Jing-Jing.

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