文献类型： 外文期刊
作者： Zhang, Zuofa 1 ; Shi, Liangen 1 ;
作者机构： 1.Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Nervous System: Neural Coordination;Immune System: Chemical Coordination and Homeostasis;Pharmacognosy: Pharmacology
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice Cis-mulberroside A (25 and 50 mg/kg) given by p o route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33 1 -68 5% inhibition), and similar results were achieved in formalin test Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed Collectively, cis-mulberroside A showed high analgesic and anti-inflammatory activities The above results will be the supporting evidence for the potential anti-rheumatoid activity of R mori in Chinese traditional medicine
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