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Effects of the polypeptide from peanut meal mixed fermentation on lipid metabolism and intestinal flora of hyperlipidemic mice

文献类型： 外文期刊

作者： Ding, Haoyue 3 ; Zhang, Huiwen 4 ; Lu, Yaqian 5 ; Jiang, Xiaoyang 6 ; Liu, Qing 7 ; Hu, Yingfen 8 ; Sun, Haiyan 2 ; Ma, Aiguo 1 ;

作者机构： 1.Qingdao Univ, Inst Nutr & Hlth, Sch Publ Hlth, Qingdao 266071, Shandong, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China

3.Qingdao Univ, Inst Nutr & Hlth, Sch Publ Hlth, Qingdao, Peoples R China

4.Weifang 2 Peoples Hosp, Weifang, Peoples R China

5.Jining 1 Peoples Hosp, Jining, Peoples R China

6.Yantaishan Hosp, Yantai, Peoples R China

7.Qingdao Univ, Women & Childrens Hosp, Qingdao, Peoples R China

8.Qingdao Univ, Inst Biomed Engn, Coll Life Sci, Qingdao, Peoples R China

9.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou, Peoples R China

关键词： peanut polypeptide; high-fat model; lipid metabolism; intestinal flora

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.1； 五年影响因子：4.2 ）

ISSN： 0022-5142

年卷期： 2023 年 103 卷 9 期

页码：

收录情况： SCI

摘要： BACKGROUNDHyperlipidemia is one of the metabolic disorders posing great threat to human health. Our previous studies have shown that the nutritional properties of peanut meal after fermentation are markedly improved, and can effectively improve hyperlipidemia caused by high-fat diet in mice. In this study, in order to facilitate the further utilization of peanut meal, the effect of peanut polypeptide (PP) from peanut meal mixed fermentation on lipid metabolism in mice fed with high-fat diet (HFD) and its possible mechanism were investigated. Fifty male C57BL/6J mice were randomly divided into five groups: normal control group (N), high-fat model group (M), PP low-dose group (PL), PP high-dose group (PH), and atorvastatin positive control group (Y). RESULTSThe results show that PP supplementation can effectively reduce the body weight of mice, decrease the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and leptin levels (P < 0.05), increase the high-density lipoprotein cholesterol (HDL-C) levels (P < 0.05), up-regulate the expression levels of ileal tight junction proteins ZO-1 and occludin (P < 0.05), reduce the hepatocyte injury and lipid accumulation caused by high-fat diet and increase the species richness of intestinal flora. CONCLUSIONPP can significantly improve hyperlipidemia and regulate intestinal flora disorders caused by hyperlipidemia. The possible mechanism may be related to the reduction of serum leptin levels and up-regulating the expression levels of the ileal tight junction proteins ZO-1 and occludin. This study provides evidence for its regulatory role in lipid metabolism and intestinal function, and provides a research basis for the potential nutritional benefits of underutilized food by-products. (c) 2023 Society of Chemical Industry.

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