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Evolutionary analysis of Hemagglutinin and neuraminidase gene variation in H1N1 swine influenza virus from vaccine intervention in China

文献类型： 外文期刊

作者： Zhao, Xinkun 1 ; Shen, Mingshuai 1 ; Cui, Li 3 ; Liu, Cun 4 ; Yu, Jieshi 5 ; Wang, Guisheng 4 ; Erdeljan, Mihajlo 6 ; Wang, Kezhou 1 ; Chen, Shumin 4 ; Wang, Zhao 1 ;

作者机构： 1.Shandong First Med Univ & Shandong Acad Med Sci, Sch Lab Anim, 6699 Qingdao Rd, Jinan 250117, Peoples R China

2.Shandong First Med Univ & Shandong Acad Med Sci, Shandong Lab Anim Ctr, 6699 Qingdao Rd, Jinan 250117, Peoples R China

3.Shandong Anim Husb Assoc, Jinan 250000, Peoples R China

4.Shandong Prov Ctr Anim Dis Control, Shandong Prov Ctr Zoonoses Epidemiol Invest & Surv, Jinan 250100, Peoples R China

5.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Peoples R China

6.Univ Novi Sad, Fac Agr, Dept Vet Med, Novi Sad 21000, Serbia

关键词： Swine influenza virus; Vaccine intervention; Genetic drift; Zoonosis

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2024 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Influenza poses a significant threat to the global economy and health. Inactivated virus vaccines were introduced in China for prevention in 2018. In this study, three pairs of hemagglutinin (HA) and neuraminidase (NA) gene sequences were obtained from three Swine influenza virus (IAV-S) inactivated vaccine strains that were marketed in China in 2018. Phylogenetic analysis was carried out with HA and NA gene sequences to investigate the relationship between vaccine use and virus genetic drift. The findings showed that the evolutionary rate of HA remained relatively stable from 2012 to 2017, with an average genetic distance of approximately 0.020731195. However, following the introduction of the swine influenza vaccine, there was a notable acceleration in the evolutionary rate of HA, accompanied by a significant increase in the genetic distance. In 2018, the value was 0.111750269, while in 2019 it was 0.176389393. In contrast, the evolution of NA was relatively smooth, with an average genetic distance of approximately 0.030386708. Finally, we demonstrated that commercial vaccines are weak neutralizers of wild strains through immunization experiments in animals. Thus, we have reason to believe that mutations in the virus favor virus evasion of vaccine immunity. Our findings suggest that vaccine use may significantly impact the evolution of the influenza virus by potentially stimulating mutations. The selection pressure of vaccine antibodies played a role in regulating the variation of IAV-S-H1N1.

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