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Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides

文献类型： 外文期刊

作者： Xia, Wei 1 ; Gao, Yuan 5 ; Fang, Xiangjun 1 ; Jin, Long 3 ; Liu, Ruiling 1 ; Wang, Li-Shu 6 ; Deng, Yangyong 4 ; Gao, Junlong 4 ; Yang, Hailong 2 ; Wu, Weijie 1 ; Gao, Haiyan 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Food Sci Inst, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Postharvest Handling Fruits,Minist Agr & R, Hangzhou 310021, Peoples R China

2.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China

3.Chacha Food Co Ltd, Hefei 230061, Peoples R China

4.Hangzhou Yaoshengji Food Co Ltd, Hangzhou 310052, Peoples R China

5.Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310023, Peoples R China

6.Med Coll Wisconsin, Dept Med, Milwaukee, WI USA

7.City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Comprehens, Canc Ctr, Duarte, CA USA

关键词： Walnut protein; Simulated digestion; Metabolic changes; Molecular docking; Inflammation; Cell experimental verification

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 445 卷

页码：

收录情况： SCI

摘要： The impact of the simulated gastrointestinal digestion process on walnut protein and the potential antiinflammatory properties of its metabolites was studied. Structural changes induced by digestion, notably in alpha-Helix, beta-Turn, and Random Coil configurations, were unveiled. Proteins over 10,000 Da significantly decreased by 35.6 %. Antioxidant activity in these metabolites paralleled increased amino acid content. Molecular docking identified three walnut polypeptides-IPAGTPVYLINR, FQGQLPR, and VVYVLR-with potent anti-inflammatory properties. RMSD and RMSF analysis demonstrated the stable and flexible interaction of these polypeptides with their target proteins. In lipopolysaccharide (LPS)-induced inflammation in normal human colon mucosal epithelial NCM460 cells, these peptides decreased 5-hydroxytryptamine (5-HT), tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) expression, while mitigating cell apoptosis and inflammation. Our study offers valuable insights into walnut protein physiology, shedding light on its potential health benefits.

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