Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization
文献类型： 外文期刊
作者： Ren, Wenkai 1 ; Ban, Junfeng 1 ; Xia, Yaoyao 1 ; Zhou, Fang 1 ; Yuan, Caihong 1 ; Jia, Huanhua 1 ; Huang, Hailan 1 ; Jiang, Mingmin 1 ; Liang, Minjian 1 ; Li, Zhaodong 1 ; Yuan, Youyong 6 ; Yin, Yulong 7 ; Wu, Hong 1 ;
作者机构： 1.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobio, Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Guangdong Technol Res Ctr Tradit Chinese Vet Med &, Guangzhou 510642, Peoples R China
3.Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Adv Drug Delivery Syst, Guangzhou 510006, Peoples R China
4.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Sericulture & Agri, Guangzhou 510640, Peoples R China
5.Guangdong Lab Anim Monitoring Inst, Key Lab Guangdong Lab Anim, Guangzhou 510663, Peoples R China
6.South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 511442, Peoples R China
7.Chinese Acad Sci, Inst Subtrop Agr, Changsha 511442, Peoples R China
期刊名称：INNOVATION （ 影响因子：32.1； 五年影响因子：32.1 ）
ISSN： 2666-6758
年卷期： 2023 年 4 卷 2 期
页码：
收录情况： SCI
摘要： Echinacea purpurea modulates tumor progression, but the underlying mechanism is poorly defined. We isolated and purified a novel homoge-neous polysaccharide from E. purpurea (EPPA), which was shown to be an arabinogalactan with a mean molecular mass (Mr) of 3.8 3 104 Da and with a-(1-> 5)-L-Arabinan as the backbone and a-L-Araf-(1->, ->6)-b-D-Galp-(1->, and ->4)-a-D-GalpA-(1-> as the side chains. Interestingly, oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile (e.g., facilitating M1 macrophages) in tumor micro -environment by single-cell RNA sequencing (scRNA-seq) analysis. More importantly, EPPA activates the inflammasome through a phagocytosis-dependent mechanism and rewires transcriptomic and metabolic profile, thereby potentiating M1 macrophage polarization. Collectively, we propose that EPPA supplementation could function as an adjuvant therapeutic strat-egy for tumor suppression.
- 相关文献
作者其他论文 更多>>
-
Improved viability of probiotics by co-encapsulation of wheat germ oil under storage and gastrointestinal conditions: Effects of drying methods and wall composition
作者：He, Bao-Lin;Cui, Rui;Wu, Hong;Hu, Teng-Gen
关键词：Lactiplantibacillus plantarum WH021; Wheat germ oil; W1/O/W2 emulsion; Co-encapsulation; Drying method; Storage stability
-
Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism
作者：Han, Ziyi;Fu, Jian;Ren, Wenkai;Gong, Aiyan;Han, Ziyi
关键词：IPA; macrophage; MAT2A; IL-1 beta
-
The hypoglycemic effect of mulberry (Morus atropurpurea) fruit lacking fructose and glucose by regulation of the gut microbiota
作者：Wang, Ya-Ting;Wu, Ji-Jun;Yu, Yuan-Shan;Wen, Jing;Zou, Bo;Li, Lu;Peng, Jian;Cheng, Li-Na;Bu, Zhi-Bin;Xu, Yu-Juan;Hu, Teng-Gen;Wang, Ya-Ting;Wu, Hong;Yu, Yuan-Shan;Yu, Yuan-Shan;Zou, Bo;Xu, Yu-Juan;Hu, Teng-Gen
关键词：
-
Synergistic combination of cinnamaldehyde with citral for improving bread preservation: inhibition of Aspergillus niger and Penicillium citrinum
作者：Tan, Jin-Ming;Cui, Rui;Wu, Hong;Hu, Teng-Gen
关键词：Fungal contamination; Natural preservative; Cinnamaldehyde; Citral; Synergistic effect; Baked products
-
Hypoglycemic effects of Lactiplantibacillus plantarum B19 via promoting AMPK/PI3K/AKT signaling pathway
作者：Xiong, Mei-Jie;Cui, Rui;Wu, Hong;Hu, Teng-Gen
关键词：Lactiplantibacillus plantarum B19; Hypoglycemic effects; Insulin resistance; AMPK/PI3K/AKT pathway; HepG2 cells
-
Palladium(
ii )-catalyzed enantioselective desymmetrization ring opening of oxabicyclic alkenes with alkynylanilines: efficient access to enantioenriched functionalized cyclohexenes作者：Tan, Binhong;Meng, Junjie;Liu, Qianru;Chen, Shixin;Li, Zhaodong;Zhang, Yuping;Zhang, Yue;Li, Zhaodong;Xue, Mingyue
关键词：
-
Brevibacillus laterosporus BL1 improves intestinal barrier function and immune homeostasis and modulates gut microbiota in high-fat diet-fed mice
作者：Weng, Guangying;Ma, Xianyong;Yu, Miao;Song, Min;Liu, Zhichang;Deng, Dun;Weng, Guangying;Deng, Jinping;Yin, Yulong;Yin, Yulong
关键词：probiotic;
Brevibacillus laterosporus ; intestinal barrier function; gut microbiota; immune homeostasis
