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Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

文献类型： 外文期刊

作者： Ren, Wenkai 1 ; Ban, Junfeng 1 ; Xia, Yaoyao 1 ; Zhou, Fang 1 ; Yuan, Caihong 1 ; Jia, Huanhua 1 ; Huang, Hailan 1 ; Jiang, Mingmin 1 ; Liang, Minjian 1 ; Li, Zhaodong 1 ; Yuan, Youyong 6 ; Yin, Yulong 7 ; Wu, Hong 1 ;

作者机构： 1.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobio, Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Guangdong Technol Res Ctr Tradit Chinese Vet Med &, Guangzhou 510642, Peoples R China

3.Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Adv Drug Delivery Syst, Guangzhou 510006, Peoples R China

4.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Sericulture & Agri, Guangzhou 510640, Peoples R China

5.Guangdong Lab Anim Monitoring Inst, Key Lab Guangdong Lab Anim, Guangzhou 510663, Peoples R China

6.South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou 511442, Peoples R China

7.Chinese Acad Sci, Inst Subtrop Agr, Changsha 511442, Peoples R China

期刊名称：INNOVATION （ 影响因子：32.1； 五年影响因子：32.1 ）

ISSN： 2666-6758

年卷期： 2023 年 4 卷 2 期

页码：

收录情况： SCI

摘要： Echinacea purpurea modulates tumor progression, but the underlying mechanism is poorly defined. We isolated and purified a novel homoge-neous polysaccharide from E. purpurea (EPPA), which was shown to be an arabinogalactan with a mean molecular mass (Mr) of 3.8 3 104 Da and with a-(1-> 5)-L-Arabinan as the backbone and a-L-Araf-(1->, ->6)-b-D-Galp-(1->, and ->4)-a-D-GalpA-(1-> as the side chains. Interestingly, oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile (e.g., facilitating M1 macrophages) in tumor micro -environment by single-cell RNA sequencing (scRNA-seq) analysis. More importantly, EPPA activates the inflammasome through a phagocytosis-dependent mechanism and rewires transcriptomic and metabolic profile, thereby potentiating M1 macrophage polarization. Collectively, we propose that EPPA supplementation could function as an adjuvant therapeutic strat-egy for tumor suppression.

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