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Type IV secretion system effector sabotages multiple defense systems in a competing bacterium

文献类型： 外文期刊

作者： Wang, Bingxin 1 ; Xu, Fugui 1 ; Zhang, Zeyu 1 ; Shen, Danyu 1 ; Wang, Limin 1 ; Wu, Huijun 1 ; Yan, Qing 2 ; Cui, Chuanbin 3 ; Wang, Pingping 3 ; Wei, Qi 4 ; Shao, Xiaolong 1 ; Wang, Mengcen 5 ; Qian, Guoliang 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Key Lab Integrated Management Crop Dis & Pests, Minist Educ, 1 Weigang, Nanjing 210095, Peoples R China

2.Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA

3.CNTC, Dept Plant Pathol, Shaanxi Prov Tobacco Corp, Xian 710061, Peoples R China

4.Heilongjiang Acad Agr Sci, Ind Crops Inst, Harbin 150086, Peoples R China

5.Zhejiang Univ, State Key Lab Rice Biol & Breeding, Hangzhou 310058, Peoples R China

6.Zhejiang Univ, Minist Agr & Rural Affairs, Lab Mol Biol Crop Pathogens & Insects, Hangzhou 310058, Peoples R China

关键词： T4SS; effector; Lysobacter; Pseudomonas; antimicrobial activity; LuxR; PvdS

期刊名称：ISME JOURNAL （ 影响因子：10.8； 五年影响因子：11.8 ）

ISSN： 1751-7362

年卷期： 2024 年 18 卷 1 期

页码：

收录情况： SCI

摘要： Effector proteins secreted by bacteria that infect mammalian and plant cells often subdue eukaryotic host cell defenses by simultaneously affecting multiple targets. However, instances when a bacterial effector injected in the competing bacteria sabotage more than a single target have not been reported. Here, we demonstrate that the effector protein, LtaE, translocated by the type IV secretion system from the soil bacterium Lysobacter enzymogenes into the competing bacterium, Pseudomonas protegens, affects several targets, thus disabling the antibacterial defenses of the competitor. One LtaE target is the transcription factor, LuxR1, that regulates biosynthesis of the antimicrobial compound, orfamide A. Another target is the sigma factor, PvdS, required for biosynthesis of another antimicrobial compound, pyoverdine. Deletion of the genes involved in orfamide A and pyoverdine biosynthesis disabled the antibacterial activity of P. protegens, whereas expression of LtaE in P. protegens resulted in the near-complete loss of the antibacterial activity against L. enzymogenes. Mechanistically, LtaE inhibits the assembly of the RNA polymerase complexes with each of these proteins. The ability of LtaE to bind to LuxR1 and PvdS homologs from several Pseudomonas species suggests that it can sabotage defenses of various competitors present in the soil or on plant matter. Our study thus reveals that the multi-target effectors have evolved to subdue cell defenses not only in eukaryotic hosts but also in bacterial competitors.

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