文献类型： 外文期刊
作者： Lu, Danqing 1 ; Wu, Yang 1 ; Fu, Mei 2 ; Wu, Yaotang 2 ; Wang, Zhisheng 3 ; Lin, Jian 1 ; Yang, Qian 2 ;
作者机构： 1.Nanjing Agr Univ, SanYa Inst, Coll Life Sci, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Wei Gang 1, Nanjing 210095, Jiangsu, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Natl Res Ctr Engn & Technol Vet Biol, Nanjing 210014, Peoples R China
4.Nanjing Agr Univ, Weigang 1, Nanjing, Jiangsu, Peoples R China
关键词： Avian ileum mucus; CALB1; Antiviral activity; Binding calcium
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2023 年 253 卷
页码：
收录情况： SCI
摘要： Intestinal mucus is the first line of defense against pathogens and has several active components. Poultry have a short intestine, the mucus of which may contain antiviral components. We hence investigated the antiviral components of mucus and explored their mechanisms of action. Initially, we isolated chicken intestinal mucus proteins that significantly inhibited the replication of avian viruses. The ileum 10-30 kDa protein fraction showed the greatest inhibition of viral replication. Moreover, liquid chromatography-mass spectrometry revealed 12 high-abundance proteins in the ileum 10-30 kDa protein fraction. Among them, we investigated the antiviral activity of calcium binding protein 1 (CALB1). Furthermore, eukaryotically and prokaryotically expressed CALB1 significantly suppressed the replication of avian viruses, possibly by binding calcium ions and/or inducing autophagy. In conclusion, we isolated and identified CALB1 from chicken intestinal mucus, which suppressed replication of avian viruses by regulating cellular calcium-ion homeostasis and autophagy.
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