文献类型： 外文期刊
作者： Li, Nian 1 ; Zhou, Yinqi 1 ; Cai, Jiali 1 ; Wang, Yifei 1 ; Zhou, Xiaofeng 1 ; Hu, Mengting 1 ; Li, Yubin 2 ; Zhang, Hao 1 ; Li, Jiaqi 1 ; Cai, Bing 2 ; Yuan, Xiaolong 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, State Key Lab Livestock & Poultry Breeding,Guangdo, Guangzhou 510642, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Reprod Med Ctr, Guangdong Prov Key Lab Reprod Med, Guangzhou 510080, Guangdong, Peoples R China
关键词： Trans-acting lncRNAs; Granulosa cells; Follicular remodeling
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2023 年 242 卷
页码：
收录情况： SCI
摘要： Previous studies have implicated the attractive role of long noncoding RNAs (lncRNAs) in the remodeling of mammalian tissues. The migration of granulosa cells (GCs), which are the main supporting cells in ovarian follicles, stimulates the follicular remodeling. Here, with the cultured GCs as the follicular model, the actin gamma 1 (ACTG1) was observed to significantly promote the migration and proliferation while inhibit the apoptosis of GCs, suggesting that ACTG1 was required for ovarian remodeling. Moreover, we identified the trans- regulatory lncRNA of ACTG1 (TRLA), which was epigenetically targeted by histone H3 lysine 4 acetylation (H3K4ac). Mechanistically, the 2-375 nt of TRLA bound to ACTG1's mRNA to increase the expression of ACTG1. Furthermore, TRLA facilitated the migration and proliferation while inhibited the apoptosis of GCs, thereby accelerating follicular remodeling. Besides, TRLA acted as a ceRNA for miR-26a to increase the expression of high-mobility group AT-hook 1 (HMGA1). Collectively, TRLA induces the remodeling of ovarian follicles via complementary to ACTG1's mRNA and regulating miR-26a/HMGA1 axis in GCs. These observations revealed a novel and promising trans-acting lncRNA mechanism mediated by H3K4ac, and TRLA might be a new target to restore follicular remodeling and development.
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