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IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner

文献类型： 外文期刊

作者： Shi, Xibao 1 ; Wei, Menglu 1 ; Feng, Yuwen 1 ; Yang, Yuanhao 1 ; Zhang, Xiaozhuan 1 ; Chen, Hao 1 ; Xing, Yuqi 1 ; Wang, Keqi 1 ; Wang, Wensheng 1 ; Wang, Li 2 ; Wang, Aiping 3 ; Zhang, Gaiping 2 ;

作者机构： 1.Henan Normal Univ, Coll Life Sci, Xinxiang, Peoples R China

2.Henan Acad Agr Sci, Key Lab Anim Immunol Minist Agr, Henan Prov Key Lab Anim Immunol, Zhengzhou, Peoples R China

3.Zhengzhou Univ, Sch Life Sci, Zhengzhou, Peoples R China

4.Peking Univ, Sch Adv Agr Sci, Beijing, Peoples R China

5.Longhu Lab Adv Immunol, Zhengzhou, Peoples R China

6.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Peoples R China

7.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China

关键词： IFN-gamma-inducible protein 16; interferon gene-stimulating protein; retinoic acid-inducible gene I; type I interferon

期刊名称：DNA AND CELL BIOLOGY （ 影响因子：3.1； 五年影响因子：3.1 ）

ISSN： 1044-5498

年卷期： 2024 年 43 卷 4 期

页码：

收录情况： SCI

摘要： Previous studies have shown that interferon gene-stimulating protein (STING) is essential for IFN-gamma-inducible protein 16 (IFI16) as the DNA sensor and RNA sensor to induce transcription of type I interferon (IFN-I) and is essential for IFI16 to synergize with DNA sensor GMP-AMP (cGAMP) synthase (cGAS) in induction of IFN-I transcription. While other and our previous studies have shown that IFI16 enhanced retinoic acid-inducible gene I (RIG-I)-, which was an RNA sensor, and mitochondrial antiviral signaling (MAVS)-, which was the adaptor protein of RIG-I, induced production of IFN-I, so we wonder whether IFI16 regulates the signal pathway of RNA-RIG-I-MAVS-IFN-I in a STING-dependent manner. We used HEK 293T cells, which did not express endogenous STING and were unable to mount an innate immune response upon DNA transfection and found that IFI16 could enhance RIG-I- and MAVS-mediated induction of IFN-I in a STING-independent way. Furthermore, we found that upregulation of the expression of NF-kappa-B essential modulator (NEMO) by IFI16 was not the mechanism that IFI16 regulated the induction of IFN-I. In conclusion, we found that IFI16 regulated the signal pathway of RNA-RIG-I-MAVS-IFN-I in a STING-independent manner.

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