Association between novel variants in BMPR1B gene and litter size in Mongolia and Ujimqin sheep breeds
文献类型： 外文期刊
作者： Gao, Yuanyuan 1 ; Hao, Qi 1 ; Cang, Ming 1 ; Wang, Jianguo 1 ; Yu, Haiquan 1 ; Liu, Yongbin 2 ; Zhang, Wenguang 3 ; Tong, 1 ;
作者机构： 1.Inner Mongolia Univ, Sch Life Sci, State Key Lab Reprod Regulat & Breeding Grassland, Hohhot 010070, Peoples R China
2.Inner Mongolia Acad Agr & Anim Husb Sci, Inst Anim Sci, Hohhot, Peoples R China
3.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot, Peoples R China
关键词： association; BMPR1B; litter size; Mongolia sheep; mutation; Ujimqin sheep
期刊名称：REPRODUCTION IN DOMESTIC ANIMALS （ 影响因子：2.005； 五年影响因子：2.154 ）
ISSN： 0936-6768
年卷期：
页码：
收录情况： SCI
摘要： Prolificacy is an important trait of animals, specifically for sheep. The Bone morphogenetic protein receptor 1B (BMPR1B) is a major gene affecting the litter size of many sheep breeds. The well-known FecB mutation (Q249R) was associated fully with the hyper prolific phenotype of Booroola Merino. However, the identification of variation in all exonic regions of BMPR1B was rare. In this study, we sequenced all exonic regions of BMPR1B gene of Mongolia sheep breed, and ten novel variants were detected by direct sequencing. Among them, the litter size of the Mongolia ewes with the CC genotype was significantly higher (0.34 additional lambs, p < .05) than those with the TT genotype of the g.29346567C>T single nucleotide polymorphism (SNP). The litter size of the Mongolia ewes with the TT genotype was significantly higher (0.19 additional lambs, p < .05 and .31 additional lambs, p < .01, respectively) than those with the GT and GG genotypes of the c.1470G>T SNP. The silent c.1470G>T mutation is predicted to increase the stability of the mRNA secondary structure through reducing minimum free energy and is predicted to change the mRNA secondary structure of BMPR1B. Our findings may give potentially useful genetic markers for increasing litter size in sheep.
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