Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice
文献类型： 外文期刊
作者： Zhang, Hao 1 ; Liu, Xiaofang 2 ; Li, Bo 1 ; Zhang, Yi 1 ; Gao, Hua 1 ; Zhao, Xianyong 2 ; Leng, Kailiang 2 ; Song, Zhenhua 1 ;
作者机构： 1.Qingdao Univ, Dept Pharmacol, Sch Pharm, Qingdao, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao, Peoples R China
关键词： major depressive disorder; CUMS; krill oil; transcriptome sequencing; lipid metabolism
期刊名称：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY （ 2022影响因子：5.5； 五年影响因子：5.8 ）
ISSN： 2296-634X
年卷期： 2023 年 11 卷
收录情况： SCI
摘要： The pathology of depression involves various factors including the interaction between genes and the environment. The deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine. However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain. We observed that CUMS-induced depression-like behaviors were ameliorated by krill oil supplementation in mice. The metabolism of glycerophospholipids and sphingolipids was disrupted by CUMS treatment, which were ameliorated after krill oil supplementation. Further analysis found that differently expressed genes after krill oil supplementation were mainly enriched in the membrane structures and neuroactive ligand-receptor interaction pathway, which may be responsible for the amelioration of CUMS-induced depression-like behaviors. Altogether, our results uncovered the relationship between lipid metabolism and CUMS, and provided new strategies for the prevention and treatment of depression.
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