Deciphering Trachinotus ovatus resistance to Streptococcus agalactiae:GWAS :GWAS identification of key SNPs and candidate genes
文献类型： 外文期刊
作者： Sun, Yi-Yao 1 ; Gao, Jie 1 ; Liu, Bao-Suo 1 ; Zhang, Nan 1 ; Guo, Hua-Yang 1 ; Zhu, Ke-Cheng 1 ; Xian, Lin 1 ; Zhang, Dian-Chang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Guangzhou 510300, Guangdong, Peoples R China
2.Hebei Agr Univ, Ocean Coll, Qinhuangdao 066000, Peoples R China
3.Sanya Trop Fisheries Res Inst, Sanya 572018, Peoples R China
4.Guangdong Prov Engineer Technol Res Ctr Marine Bio, Guangzhou, Guangdong, Peoples R China
5.Sun Yat sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China
关键词： GWAS; Trachinotus ovatus; Streptococcus agalactiae; SNP
期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.1 ）
ISSN： 0044-8486
年卷期： 2025 年 594 卷
页码：
收录情况： SCI
摘要： The genetic basis of resistance in Trachinotus ovatus to Streptococcus agalactiae, , a prevalent pathogen in warm- water fish, was explored in this study. T. ovatus, , an economically significant marine fish, is widely distributed in tropical and subtropical oceans. This research involved the whole-genome resequencing of 200 T. ovatus individuals and a genome-wide association study (GWAS) to identify significant single nucleotide polymorphisms (SNPs) associated with resistance to S. agalactiae. . Methods included infection experiments with S. agalactiae, , quality control of DNA samples, high-throughput sequencing, SNP detection and quality control, analysis of population genetic structure, linkage disequilibrium (LD) analysis, GWAS, screening of candidate genes, and genotyping of significant SNPs. Results indicated a significant association of specific SNP loci with resistance in T. ovatus to S. agalactiae, , notably SNP18597184 on chromosome LG9, associated with the NTRK3 and IFNK genes involved in neural development, survival, and immune response.
- 相关文献
作者其他论文 更多>>
-
Early development and allometric growth patterns of Larimichthys crocea (Richardson, 1846)
作者：Liu, Bo -Wen;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian -Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian -Chang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian -Chang;Liu, Bo -Wen;Sun, Jin-Hui;Yan, Kuo-Qiu;Zhang, Dian -Chang
关键词：Larimichthys crocea; Early development; Morphology; Allometric
-
Identification of two MEF2s and their role in inhibiting the transcription of the mstn2a gene in the yellowfin seabream, Acanthopagrus latus (Hottuyn, 1782)
作者：Zhu, Kecheng;He, Hongxi;Guo, Huayang;Liu, Baosuo;Zhang, Nan;Xian, Lin;Zhang, Dianchang;Zhu, Kecheng;Guo, Huayang;Liu, Baosuo;Zhang, Nan;Xian, Lin;Zhang, Dianchang;Zhu, Kecheng;Guo, Huayang;Liu, Baosuo;Zhang, Nan;Xian, Lin;Zhang, Dianchang;Zhang, Dianchang
关键词：Acanthopagrus latus; MEF2; Mstn2a; Point mutation; EMSA
-
Characterization of the Galectin-3 gene and its association with Streptococcus iniae resistance traits in Acanthopagrus latus (Houttuyn, 1782)
作者：Pan, Jin-Min;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang;Pan, Jin-Min;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang
关键词：Acanthopagrus latus; Streptococcus iniae; Single nucleotide polymorphisms; Galectin-3
-
Genome-wide characterization, phylogenetic and expression analysis of Galectin gene family in Golden pompano Trachinotus ovatus
作者：Pan, Jin-Min;Liang, Yu;Zhu, Ke-Cheng;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Zhu, Ke-Cheng;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Zhu, Ke-Cheng;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Zhu, Ke-Cheng;Guo, Hua-Yang;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Liu, Bao-Suo
关键词：Galectins; Golden pompano; subcellular localization; protein function; bacterial agglutination
-
Establishment and identification of the head kidney cell line of yellowfin seabream ( Acanthopagrus latus) ) and its application in a virus susceptibility study
作者：Yang, Hui-Yuan;Zhu, Ke-Cheng;Guo, Hua-Yang;Zhang, Nan;Liu, Bao-Suo;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Yang, Hui-Yuan;Guo, Ran;Zhu, Ke-Cheng;Guo, Hua-Yang;Zhang, Nan;Liu, Bao-Suo;Xian, Lin;Zhu, Teng-Fei;Zhang, Dian-Chang;Zhu, Ke-Cheng;Guo, Hua-Yang;Zhang, Nan;Liu, Bao-Suo;Zhang, Dian-Chang
关键词：Acanthopagrus latus; Yellowfin seabream; Head kidney; Cell line; Immune genes; Virus
-
Two IFNa3s mediate the regulation of IRF9 in the process of infection with Streptococcus iniae in yellowfin seabream, Acanthopagrus latus (Hottuyn, 1782)
作者：He, Hong-Xi;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian-Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian-Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian-Chang
关键词：Acanthopagrus latus; IRF9; IFN; Subcellular localization
-
Genome-wide identification of heat shock protein gene family and their responses to pathogen challenge in Trachinotus ovatus
作者：Sun, Yi-Yao;Yang, Hui-Yuan;Sun, Yi-Yao;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Xian, Lin;Zhao, Peng-Hai;Yang, Hui-Yuan;Zhang, Dian-Chang;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Xian, Lin;Zhang, Dian-Chang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian-Chang;Zhang, Dian-Chang
关键词：Heat shock proteins; T.ovatus; Phylogenetic analysis; Expression analysis
