Deciphering Trachinotus ovatus resistance to Streptococcus agalactiae:GWAS :GWAS identification of key SNPs and candidate genes
文献类型： 外文期刊
作者： Sun, Yi-Yao 1 ; Gao, Jie 1 ; Liu, Bao-Suo 1 ; Zhang, Nan 1 ; Guo, Hua-Yang 1 ; Zhu, Ke-Cheng 1 ; Xian, Lin 1 ; Zhang, Dian-Chang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Guangzhou 510300, Guangdong, Peoples R China
2.Hebei Agr Univ, Ocean Coll, Qinhuangdao 066000, Peoples R China
3.Sanya Trop Fisheries Res Inst, Sanya 572018, Peoples R China
4.Guangdong Prov Engineer Technol Res Ctr Marine Bio, Guangzhou, Guangdong, Peoples R China
5.Sun Yat sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China
关键词： GWAS; Trachinotus ovatus; Streptococcus agalactiae; SNP
期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.1 ）
ISSN： 0044-8486
年卷期： 2025 年 594 卷
页码：
收录情况： SCI
摘要： The genetic basis of resistance in Trachinotus ovatus to Streptococcus agalactiae, , a prevalent pathogen in warm- water fish, was explored in this study. T. ovatus, , an economically significant marine fish, is widely distributed in tropical and subtropical oceans. This research involved the whole-genome resequencing of 200 T. ovatus individuals and a genome-wide association study (GWAS) to identify significant single nucleotide polymorphisms (SNPs) associated with resistance to S. agalactiae. . Methods included infection experiments with S. agalactiae, , quality control of DNA samples, high-throughput sequencing, SNP detection and quality control, analysis of population genetic structure, linkage disequilibrium (LD) analysis, GWAS, screening of candidate genes, and genotyping of significant SNPs. Results indicated a significant association of specific SNP loci with resistance in T. ovatus to S. agalactiae, , notably SNP18597184 on chromosome LG9, associated with the NTRK3 and IFNK genes involved in neural development, survival, and immune response.
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