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Selenium-rich Lactobacillus plantarum alleviates salinity stress in Cyprinus carpio: Growth performance, oxidative stress, and immune and inflammatory responses

文献类型： 外文期刊

作者： Che, Xinghua 1 ; Geng, Longwu 1 ; Zhang, Qing 1 ; Wei, Haijun 1 ; He, Hailong 3 ; Xu, Wei 1 ; Shang, Xinchi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Key Open Lab Cold Water Fish Germplasm Resources &, Harbin 150070, Peoples R China

2.Chinese Acad Fishery Sci, Engn Technol Res Ctr Saline Alkaline Water Fisheri, Harbin 150070, Peoples R China

3.Heilongjiang Aquat Anim Resource Conservat Ctr, Harbin, Peoples R China

4.Northeast Agr Univ, Coll Life Sci, Harbin 150036, Peoples R China

关键词： Selenium -rich Lactobacillus plantarum; Salinity stress; Antioxidants; Inflammatory responses; Cyprinus carpio

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：3.8 ）

ISSN： 2352-5134

年卷期： 2024 年 36 卷

页码：

收录情况： SCI

摘要： Salinity is an important environmental factor that affects the health of aquatic animals, when salinity level above the tolerance threshold can pose a significant threat to the survival of aquatic animals. As a trace element necessary for animal growth, selenium participates in the body's antioxidant reaction, and protect aquatic animals from oxidative stress damage. Biological methods for synthesizing selenium nanoparticles (bio-Se-NPs) from bacteria are safe, inexpensive, and accessible. Therefore, we synthesized selenium nanoparticles using Lactobacillus plantarum (probiotic) to study the growth, immune, antioxidant, and inflammatory responses of selenium-rich Lactobacillus plantarum (SL, a type of bio-Se-NPs) fed Cyprinus carpio under low-salinity (5 g/L salinity) and high-salinity (10 g/L salinity) stresses. Analyses revealed that the addition of SL at a concentration of 1 mg/kg significantly alleviated the growth inhibition caused by high-salinity stress. SL significantly alleviated salinity-induced liver tissue injury (numerous cytoplasmic vacuolations the accumulation, inflammatory cell infiltration, nuclear lysis, and some blood congestion). SL significantly alleviated the abnormal levels of serum ALT, AST, GGT and LDH caused by salinity stress, and improved lipid metabolism (TG, TC, LDL-C, HDL-C). SL can also regulates cytokines and antioxidant genes (TNF-alpha, iL-1 beta, iL-10, TGF beta-1, SOD, CAT, GPx1, and HO-1) through the NF-kappa B and Nrf-2 signaling pathways and thereby reduce the inflammatory response and increase the antioxidant level, and these effects attenuate salinity-mediated oxidative damage. In conclusion, our findings indicate that SL can significantly promote the growth and development of fish and alleviate the adverse effects of high-salinity stress and thus, SL can be a potential feed additive for alleviating oxidative stress and inflammatory responses.

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