Enhancing butyrate synthesis and intestinal epithelial energy supply through mixed probiotic intervention in dextran sulfate sodium-induced colitis
文献类型： 外文期刊
作者： Zhang, Heng 1 ; Sun, Jingzhou 1 ; Xie, Aowen 1 ; Yang, Huiqin 1 ; Li, Yingjun 1 ; Mei, Yuxia 1 ; Li, Jinshan 1 ; Xiao, Lei 1 ; Liu, Yangyang 1 ; Liang, Yunxiang 1 ;
作者机构： 1.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China
3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Minist Agr, Key Lab Freshwater Biodivers Conservat, Wuhan 430223, Peoples R China
关键词： Probiotics; Gut microbiota; Butyrate synthesis; Inflammatory bowel disease; Energy supply
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）
ISSN： 2212-4292
年卷期： 2025 年 63 卷
页码：
收录情况： SCI
摘要： Inflammatory bowel disease (IBD) is a globally prevalent gastrointestinal disorder that considerably impairs life quality. Probiotics are considered potential therapeutic agents for IBD because of their multifaceted effects. In this study, we evaluated the therapeutic effects of a mixture of probiotics (Lactobacillus rhamnosus, Lactobacillus plantarum, and Clostridium butyricum) on dextran sulfate sodium (DSS)-induced colitis in mice. To determine its anti-inflammatory mechanism, we employed metagenomic sequencing to analyze the effects of mixed probiotics on butyrate-producing bacteria and related genes in the gut. Immunofluorescence, immunohistochemistry, and flow cytometry were used to detect the effects of mixed probiotics on the intestinal barrier, immune function, and mitochondrial function in mice. Finally, in vitro fermentation experiments were conducted to evaluate the antiinflammatory effects of the intestinal flora in mice relative to antibiotics. Our findings demonstrated that mixed probiotics enhance the conversion of lactate to butyrate by restoring the acetyl-CoA pathway in the colonic microbiota of mice with DSS-induced colitis. This restoration, in turn, led to the restoration of butyrate levels in the intestine and the activation of the butyrate receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) to sustain the energy supply of intestinal epithelial cells. Consequently, this intervention reinforced the intestinal barrier integrity and modulated intestinal immune responses. In conclusion, mixed probiotics alleviate colitis, providing a potential therapeutic strategy for IBD.
- 相关文献
作者其他论文 更多>>
-
Effects of western boundary currents and sea surface temperature anomalies on interannual variability of chub mackerel abundance in the Northwest Pacific
作者：Li, Jiasheng;Zhou, Weifeng;Dai, Yang;Tang, Fenghua;Wu, Yumei;Zhang, Heng;Fan, Xiumei;Cui, Xuesen;Li, Jiasheng
关键词：Chub mackerel; Abundance; Kuroshio; Oyashio; Sea surface temperature anomaly; Northwest Pacific
-
Comparative Analysis of Prediction Models for Trawling Grounds of the Argentine Shortfin Squid Illex argentinus in the Southwest Atlantic High Seas Based on Vessel Position and Fishing Log Data
作者：Xiang, Delong;Sun, Yuyan;Zhu, Hanji;Wang, Jianhua;Huang, Sisi;Zhang, Shengmao;Zhang, Famou;Zhang, Heng;Xiang, Delong;Sun, Yuyan;Huang, Sisi;Zhang, Shengmao;Zhang, Famou;Zhang, Heng;Xiang, Delong;Sun, Yuyan;Huang, Sisi;Zhang, Shengmao;Zhang, Famou;Zhang, Heng;Zhu, Hanji;Wang, Jianhua
关键词：Southwest Atlantic;
Illex argentinus ; AIS; deep learning; fishing ground prediction -
Mechanisms of hepatic dysfunction in Nile tilapia (Oreochromis niloticus) fed a high-fava bean (Vicia faba L.) diet
作者：Zhang, Xinyao;Zhang, Xinyao;Cheng, Ke;Dong, Lixue;Tian, Juan;Peng, Di;Zhang, Jianmin;Liu, Yangyang;Wen, Hua;Jiang, Ming;Zhu, Dexing;Li, Qingyong;Guo, Zhongbao;Luo, Yongju;Liu, Apeng
关键词：Tilapia; Fava bean; Muscle texture; Liver health; Metabolomics
-
The Effects of Climate Change on Sthenoteuthis oualaniensis Habitats in the Northern Indian Ocean
作者：Wen, Lihong;Fang, Zhou;Chen, Xinjun;Wen, Lihong;Zhang, Heng;Fang, Zhou;Chen, Xinjun;Fang, Zhou;Chen, Xinjun;Fang, Zhou;Chen, Xinjun
关键词：climate change; environmental factors;
Sthenoteuthis oualaniensis ; habitat; northern Indian Ocean -
Simulation and Identification of the Habitat of Antarctic Krill Based on Vessel Position Data and Integrated Species Distribution Model: A Case Study of Pumping-Suction Beam Trawl Fishing Vessels
作者：Zhang, Heng;Sun, Yuyan;Zhu, Hanji;Xiang, Delong;Wang, Jianhua;Zhang, Famou;Huang, Sisi;Li, Yang;Zhang, Heng;Xiang, Delong;Huang, Sisi;Zhang, Heng;Zhu, Hanji;Wang, Jianhua;Li, Yang;Sun, Yuyan;Xiang, Delong;Zhang, Famou;Huang, Sisi
关键词：Antarctic krill; vessel position data; environmental data; species distribution model; habitat research
-
Comparative analysis of modeling methods and prediction accuracy for Japanese sardine habitat under three climate scenarios with differing greenhouse emission pathways
作者：Sun, Yuyan;Xiang, Delong;Wang, Jianhua;Jiang, Keji;Zhu, Hanji;Huang, SiSi;Zhang, Famou;Li, Yang;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Jiang, Keji;Huang, SiSi;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Jiang, Keji;Huang, SiSi;Zhang, Famou;Zhang, Heng;Wang, Jianhua;Zhu, Hanji;Li, Yang
关键词：Japanese sardine; Species distribution models (SDMs); Climate change; Spatial resolution; Species presence data points
-
The Spatio-Temporal Distribution and Population Dynamics of Chub Mackerel (Scomber japonicus) in the High Seas of the Northwest Pacific Ocean
作者：Zhao, Guoqing;Zhang, Heng;Tang, Fenghua;Zhao, Guoqing
关键词：biological characteristics;
Scomber japonicus ; stock assessment; LBB; fishing ground; Northwest Pacific Ocean
