文献类型： 外文期刊
作者： Zheng, Li 1 ; Xu, Jiawei 2 ; Liu, Xian 3 ; Zhang, Zijing 4 ; Zhong, Jialin 2 ; Wen, Yifan 2 ; Yao, Zhi 2 ; Yang, Peng 2 ; Wang, Eryao 4 ; Chen, Fuying 4 ; Huang, Weihong 5 ; Qi, Zengfang 5 ; Yang, Guojie 5 ; Lei, Chuzhao 2 ; Chen, Hong 2 ; Ru, Baorui 3 ; Huang, Yongzhen 2 ;
作者机构： 1.Henan Univ Anim Husb & Econ, Zhengzhou 450046, Henan, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
3.Henan Prov Anim Husb Gen Stn, Zhengzhou 450008, Henan, Peoples R China
4.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China
5.Jiaxian Anim Husb Bur, Jiaxian 467100, Henan, Peoples R China
关键词： Association analysis; Body size; Cattle; CNV; MAS
期刊名称：3 BIOTECH （ 影响因子：2.893； 五年影响因子：3.446 ）
ISSN： 2190-572X
年卷期： 2022 年 12 卷 4 期
页码：
收录情况： SCI
摘要： Copy number variations (CNVs) belong to mutations in the genome level with loci in the region of genic or intergenic. It is through different effects (such as position effect and dose effect) that influence complex traits and diseases. Deleted in Malignant Brain Tumors 1 (DMBT1) gene is a member of the scavenger receptor cysteine-rich super family. In cattle, this gene has been associated with the susceptibility to bovine tuberculosis. In this study, a new CNV was found in DMBT1 gene of Chinese cattle breeds and tested in two different Chinese cattle breeds (Jiaxian red and Pinan) for frequency distribution analysis. Besides, the body size data such as body length, body height, chest girth, chest width, rump length, and rump girth for Jiaxian (JX) and Pinan (PN) cattle were collected and associated with the newly identified CNV. The CNV was significantly associated with the body length and chest girth of JX cattle, and the rump length of PN cattle (P < 0.05). Furthermore, the expression profile of the DMBT1 gene was tested in calves' tissues and the myoblasts differentiation. It was found that the DMBT1 gene expression was high in tuberculosis susceptible tissues (liver and lungs) at the calf stage and high in myoblast early differentiation. These tests were done using the qPCR method. As the result, the CNV of DMBT1 gene could be used as a candidate marker for bovine growth and health in marker-assisted selection (MAS) breeding.
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