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Chlorothalonil drives the antibiotic resistome in earthworm guts

文献类型： 外文期刊

作者： Qiu, Mengting 1 ; Wu, Zishan 1 ; Song, Jiajin 1 ; Zheng, Conglai 1 ; Zhan, Xiuping 3 ; Shan, Mei 1 ; Cui, Minrong 1 ; Chen, Liezhong 2 ; Zhang, Luqing 1 ; Yu, Yunlong 1 ; Fang, Hua 1 ;

作者机构： 1.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Key Lab Mol Biol Crop Pathogens & Insects, Coll Agr & Biotechnol,Zhejiang Prov Key Lab Biol C, Hangzhou 310058, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

3.Shanghai Agr Technol Extens Serv Ctr, Shanghai 201103, Peoples R China

关键词： Fungicide; Gut microbiome; Antibiotic resistance genes; Soil; Earthworm

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2024 年 463 卷

页码：

收录情况： SCI

摘要： Earthworms are recognized as carriers of pollutants; however, how fungicide residues affect microbiota and antibiotic resistance genes (ARGs) in earthworm guts has remained unclear. In this work, changes in the earthworm gut microbiome and resistome were investigated after chlorothalonil (CTL) application. Earthworm activity accelerated the dissipation of CTL in soil, while metagenomic analysis revealed that CTL altered the ARG profile, leading to an increased abundance of ARGs in earthworm guts, particularly with respect to ARG subtypes CRP and OXA-427. CTL also reduced bacterial diversity and elevated the relative abundance of the phylum Proteobacteria, including a potential ARG host, Aeromonas, which is a known pathogen. Various bacterial genera from the Actinobacteria and Proteobacteria phyla were identified as broad-spectrum hosts for ARGs in earthworm guts. CTL could increase the abundance of multidrug efflux pump genes and enhance the abundance of mobile genetic elements, especially plasmids. Various co-occurrence patterns between plasmids and ARGs were also found after CTL treatments. It is concluded that CTL may act as a selective stress for ARGs and lead to an increase in their abundance by facilitating the proliferation of potential ARG hosts and enhancing plasmidmediated horizontal transfer frequency of ARGs in earthworm guts.

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