文献类型： 外文期刊
作者： Li, Qianwen 1 ; Qi, Zhao 1 ; Fu, Dandan 1 ; Tang, Bo 3 ; Song, Xiangjun 1 ; Shao, Ying 1 ; Tu, Jian 1 ; Qi, Kezong 1 ;
作者机构： 1.Anhui Agr Univ, Coll Anim Sci & Technol, Anhui Prov Key Lab Vet Pathobiol & Dis Control, Hefei 230036, Peoples R China
2.Anhui Agr Univ, Coll Anim Sci & Technol, Anhui Prov Engn Lab Anim Food Qual & Biosafety, Hefei 230036, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing, Peoples R China
4.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Bioprod Engn & Technol, Nanjing, Peoples R China
5.Jiangsu Acad Agr Sci, Guotai Taizhou Vet Biotechnol Innovat Ctr, Nanjing, Peoples R China
关键词： APEC; ETT2; effector; EspE3; pathogenicity
期刊名称：VETERINARY RESEARCH （ 影响因子：4.4； 五年影响因子：4.3 ）
ISSN： 0928-4249
年卷期： 2023 年 54 卷 1 期
页码：
收录情况： SCI
摘要： APEC encodes multiple virulence factors that have complex pathogenic mechanisms. In this study, we report a virulence factor named EspE3, which can be secreted from APEC. This protein was predicted to have a leucine-rich repeat domain (LRR) and may have a similar function to IpaH class effectors of the type III secretion system (T3SS). For further exploration, the regulatory correlation between the espE3 and ETT2 genes in APEC was analysed. We then assessed the pathogenicity of EspE3, detected it in APEC secretion proteins and screened the proteins of EspE3 that interact with chicken trachea epithelial cells. This study provides data on a new virulence factor for further exploring the pathogenic mechanism of APEC.
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