文献类型： 外文期刊
作者： Li, Zhidong 1 ; Khan, Wasi Ullah 1 ; Bai, Genxiang 3 ; Dong, Chao 4 ; Wang, Jungang 5 ; Zhang, Youpeng 1 ; Wang, Chong 1 ; Zhang, Hongbin 1 ; Wang, Wenyi 6 ; Luo, Ming 3 ; Chen, Fei 1 ;
作者机构： 1.Hainan Univ, Coll Breeding & Multiplicat, Natl Key Lab Trop Crop Breeding, Sanya Inst Breeding & Multiplicat, Sanya 572025, Peoples R China
2.Hainan Univ, Coll Trop Agr & Forestry, Danzhou 571737, Peoples R China
3.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Peoples R China
4.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
5.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
6.South China Agr Univ, Coll Agr, Guangzhou 510642, Peoples R China
关键词： artificial intelligence; CRISPR; deep learning; genome editing; gene regulation
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2025 年 12 卷 30 期
页码：
收录情况： SCI
摘要： Genome editing has revolutionized modern biotechnology, enabling precise modifications to DNA sequences with far-reaching applications in medicine, agriculture, and synthetic biology. Recent advancements in artificial intelligence (AI) have significantly enhanced genome editing by improving target selection, minimizing off-target effects, and optimizing CRISPR-associated systems. AI-driven models, such as deep learning-based predictors and protein language models, enable more accurate sgRNA design, novel Cas protein discovery, and enhanced gene regulatory network analysis. Additionally, AI-powered tools facilitate large-scale data integration, accelerating functional genomics and therapeutic genome editing. This review explores the intersection of AI and genome editing, highlighting key innovations, challenges, and future prospects. Despite its transformative potential, AI-driven genome editing raises ethical concerns regarding data bias, algorithmic transparency, and unintended genetic modifications. Addressing these challenges requires interdisciplinary collaboration between AI researchers, molecular biologists, and policymakers. As AI continues to evolve, its integration with genome editing will pave the way for groundbreaking advancements in precision medicine, genetic disease treatment, and sustainable agriculture.
- 相关文献
作者其他论文 更多>>
-
Blockchain-Empowered H-CPS Architecture for Smart Agriculture
作者：Wang, Xiaoding;Wu, Qibin;Que, Youxiong;Wang, Xiaoding;Zeng, Haitao;Yang, Xu;Cui, Hui;Yi, Xun;Piran, Md. Jalil;Luo, Ming;Que, Youxiong
关键词：blockchain; human-cyber-physical systems; prospect; semantic blockchain; smart agriculture
-
High-precision identification transgenic sugarcane using active terahertz low-frequency excitation
作者：Tu, Shan;Song, Zhongzhou;Pang, Senhao;He, Qilin;Su, Jingkai;Zhang, Cheng;Xiao, Heng;Hu, Junhui;Wang, Jungang;Liu, Xihui;Tu, Shan;Zhang, Wentao
关键词：Transgenic sugarcane; THz detection; Feature extraction; Data splitting; Deep Learning
-
International research initiative on genomics-guided sugarcane breeding
作者：Zhang, Xingtan;Wang, Jungang;Que, Youxiong;Lin, Jishan;Zhang, Xingtan;Noor-ul-Ain;Abid, Javeria;Wang, Ren;Zhang, Jisen;Bao, Yixue;Zhang, Muqing;Zhang, Jisen;Bao, Yixue;Zhang, Muqing;Zhao, Peifang;Zhang, Yuebin;Chen, Li-yu;Ming, Ray;Herry, Robert;Tangphatsornruang, Sithichoke;Wang, Qinnan;Wang, Qinnan;Huang, Dongliang;Ye, Jian;Luo, Ming;Butterfield, Mike
关键词：
-
Water lily pond: a multiomics database for water lilies
作者：Zhao, Chengjun;Zhang, Ji;Chen, Yayu;Yang, Lishuang;Chen, Hongliang;Liang, Yufan;Wang, Wenquan;He, Shuang;Luo, Yunqing;Zhang, Junyu;Zhang, Hongbin;Yang, Shuting;Guo, Guilian;Dai, Wenbai;Yang, Zhijuan;Khan, Wasi Ullah;Chen, Fei;Zhao, Chengjun;Zhang, Ji;Chen, Yayu;Yang, Lishuang;Chen, Hongliang;Liang, Yufan;Wang, Wenquan;He, Shuang;Luo, Yunqing;Zhang, Junyu;Zhang, Hongbin;Yang, Shuting;Guo, Guilian;Dai, Wenbai;Khan, Wasi Ullah;Chen, Fei;Chen, Junhao;Zhou, Yuhan;Zhang, Liangsheng;Liu, Guanhua;Jiang, Yifan;Xu, Yingchun;Xue, Jia-yu;Zhu, Tianlong;Garcia-Caparros, Pedro;van de Peer, Yves;van de Peer, Yves;van de Peer, Yves;van de Peer, Yves;Chen, Chengjie
关键词：
-
Research on the ecological-economic effects of combined planting-breeding modes: a case study of Zizania latifolia-shelduck in China
作者：Teng, Wangtengfei;Xu, Lidan;Li, Zhidong;Liu, Moucheng;Rao, Didi;Wan, Qi
关键词：ecological agriculture; combined planting-breeding modes; agricultural carbon footprint; agricultural heritage; ecological compensation
-
Pan-genome and haplotype map of cassava cultivars and wild ancestors provide insights into its adaptive evolution and domestication
作者：Xia, Zhiqiang;Zhou, Xincheng;Jiang, Sirong;Chen, Fei;Zou, Meiling;Xu, Liangye;Guo, Xin;Wang, Shujuan;Li, Mengtao;Liu, Shisheng;Bao, Yuting;Zhang, Chenji;Xiao, Jianjia;Guo, Fengguang;Shen, Xu;Li, Haozheng;Zhang, Huaifang;He, Shuang;Wan, Yinglang;Chen, Yinhua;Huang, Dongyi;Li, Bin;Peng, Ming;Chen, Xin;Wang, Wenquan;Du, Zhenglin;Chen, Meili;Zhao, Wenming;Xiao, Jingfa;Du, Zhenglin;Chen, Meili;Zhao, Wenming;Xiao, Jingfa;Zhou, Xincheng;Wang, Haiyan;Lu, Cheng;Peng, Ming;Chen, Xin;Zhu, Tingting;Wang, Le;Luo, Ming-Cheng;Qiao, Fei;Li, Kaimian;Carvalho, Luiz;Lopez-Lavalle, Luis Augusto Becerra;Zhang, Xiaofei;Ceballos, Hernan;Wang, Zhenyu;Li, Yuanchao;Zhao, Long;Yan, Huabing;Qin, Xiaochun;Ma, Ling;Zhang, Weixiong;Moller, Birger Lindberg
关键词：genome; pan-genome; structural variations; selective sweeping; evolution and domestication; cassava
-
Designing a Theoretical Framework for Ecosystem Products of Agricultural Heritage Systems
作者：Ye, Ruyu;Liu, Moucheng;Ye, Ruyu;Li, Zhidong
关键词：globally important agricultural heritage systems; ecosystem products of agricultural heritage system (EPAHS); specificities of EPAHS; classifications of EPAHS; value realization pathways; evaluation
