Study on the Characteristics of Coarse Feeding Tolerance of Ding'an Pigs: Phenotypic and Candidate Genes Identification
文献类型： 外文期刊
作者： Song, Yanxia 1 ; Xue, Mingming 2 ; Wang, Feng 3 ; Tang, Qiguo 2 ; Luo, Yabiao 2 ; Zheng, Meili 4 ; Wang, Yubei 1 ; Xue, Pengxiang 2 ; Dong, Ningqi 1 ; Sun, Ruiping 3 ; Fang, Meiying 1 ;
作者机构： 1.Sanya Inst China Agr Univ, Sanya 572024, Peoples R China
2.China Agr Univ, Coll Anim Sci & Technol,MOA Key Lab Anim Genet & B, Frontiers Sci Ctr Mol Design Breeding,Beijing Key, Frontiers Sci Ctr Mol Design Breeding,Dept Anim Ge, Beijing 100193, Peoples R China
3.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Peoples R China
4.Beijing Gen Stn Anim Husb, Beijing 100107, Peoples R China
关键词： Ding'an pigs; Hainan pigs; coarse feeding tolerance; crude fiber; transcriptome sequencing; WGCNA
期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）
ISSN：
年卷期： 2024 年 15 卷 5 期
页码：
收录情况： SCI
摘要： Ding'an (DA) pig, a prominent local breed in Hainan Province, exhibits notable advantages in coarse feeding tolerance and high-quality meat. To explore the potential genetic mechanism of coarse feeding tolerance in DA pigs, 60-day-old full sibling pairs of DA and DLY (Duroc-Landrace-Yorkshire) pigs were subjected to fed normal (5%) and high (10%) crude fiber diets for 56 days, respectively. The findings showed that increasing the crude fiber level had no impact on the apparent digestibility of crude fiber, intramuscular fat, and marbling scores in DA pigs, whereas these factors were significantly reduced in DLY pigs (p < 0.05). Through differential expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA) of the colonic mucosal transcriptome data, 65 and 482 candidate genes with coarse feeding tolerance in DA pigs were identified, respectively. Joint analysis screened four key candidate genes, including LDHB, MLC1, LSG1, and ESM1, potentially serving as key regulated genes for coarse feeding tolerance. Functional analysis revealed that the most significant pathway enriched in differential genes associated with coarse feeding tolerance in Ding'an pigs was the signaling receptor binding. The results hold substantial significance for advancing our understanding of the genetic mechanisms governing coarse feeding tolerance in Ding'an pigs.
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