Fluxapyroxad induced toxicity of earthworms: Insights from multi-level experiments and molecular simulation studies
文献类型： 外文期刊
作者： Zhang, Lanlan 1 ; Liu, Yao 2 ; Xu, Ying 1 ; Pei, Mengyuan 1 ; Yao, Mengyao 1 ; Chen, Xiaoni 1 ; Cui, Yifei 1 ; Han, Fengyang 3 ; Lu, Yubo 1 ; Zhang, Cheng 1 ; Wang, Yanhua 5 ; Gao, Peng 6 ; Zhu, Lusheng 8 ; Wang, Jun 8 ;
作者机构： 1.Jiangnan Univ, Sch Environm & Ecol, Wuxi 214122, Peoples R China
2.Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China
3.Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
4.Univ Pittsburgh, Computat Chem Genom Screening Ctr, Sch Pharm, Pittsburgh, PA 15261 USA
5.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
6.Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15261 USA
7.Univ Pittsburgh, Dept Civil & Environm Engn, Pittsburgh, PA 15261 USA
8.Shandong Agr Univ, Key Lab Agr Environm Univ Shandong, Coll Resources & Environm, Tai An 271018, Peoples R China
关键词： Eisenia fetida; Fungicide; Intestinal injury; Molecular docking; Neurotoxicity
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）
ISSN： 0304-3894
年卷期： 2024 年 480 卷
页码：
收录情况： SCI
摘要： Fluxapyroxad, an emerging succinate dehydrogenase inhibitor fungicide, is widely used due to its excellent properties. Given its persistence in soil with a 50 % disappearance time of 183-1000 days, it is crucial to evaluate the long-term effects of low-dose fluxapyroxad on non-target soil organisms such as earthworms ( Eisenia fetida). The present study investigated the impacts of fluxapyroxad (0.01, 0.1, and 1 mg kg(-1 )) on Eisenia fetida over 56 days, focusing on oxidative stress, digestive and nervous system functions, and histopathological changes. We also explored the mechanisms of fluxapyroxad-enzyme interactions through molecular docking and dynamics simulations. Results demonstrated a significant dose-response relationship in the integrated biomarker response of 12 biochemical indices. Fluxapyroxad altered expression levels of functional genes and induced histopatho- logical damage in earthworm epidermis and intestines. Molecular simulations revealed that fluxapyroxad is directly bound to active sites of critical enzymes, potentially disrupting their structure and function. Even at low doses, long-term fluxapyroxad exposure significantly impacted earthworm physiology, with effects becoming more pronounced over time. Our findings provide crucial insights into the chronic toxicity of fluxapyroxad and emphasize the importance of long-term, low-dose studies in pesticide risk assessment in soil. This research offers valuable guidance for the responsible management and application of fungicides.
- 相关文献
作者其他论文 更多>>
-
In-situ structural modification on spinel oxide to achieve efficient removal of refractory organics: Triple optimisation of degradation performance
作者：Chen, Yaoning;Zhou, Wencheng;Kang, Huayue;Zhao, Mengyang;Wang, Jun;Zhao, Chen;Zou, Bin;Jia, Xuyang;Chen, Yaoning;Zhou, Wencheng;Kang, Huayue;Zhao, Mengyang;Wang, Jun;Zhao, Chen;Zou, Bin;Jia, Xuyang;Li, Yuanping;Zhang, Wei;Liu, Yihuan
关键词：Spinel oxide; Photocatalysis; Heterogeneous structures; Oxygen vacancies; Peroxymonosulfate
-
Combined effects of acetamiprid and tetraconazole on enzyme activity and gene expression in the earthworm-soil system
作者：An, Xuehua;Deng, Meihua;Li, Xinfang;Tang, Tao;Wang, Yanhua;Cao, Chong
关键词：Pesticide mixture; Soil invertebrates; Biomarkers; Biological monitoring
-
Nitrogen-doped carbon modified with boron atoms activating peroxydisulfate for sulfamethoxazole degradation: The electron transfer-dominated pathway
作者：Chen, Yaoning;Zhao, Chen;Li, Yuanping;Zhao, Mengyang;Kang, Huayue;Jiang, Hongjuan;Chen, Li;Wang, Jun;Zhou, Wencheng;Chen, Yaoning;Zhao, Chen;Zhao, Mengyang;Kang, Huayue;Jiang, Hongjuan;Chen, Li;Wang, Jun;Zhou, Wencheng;Li, Yuanping;Chi, Nianping;Liu, Yihuan
关键词：Peroxydisulfate; Non-radical pathway; Electron transfer pathway; High stability
-
Influence of triflumezopyrim and triadimefon co-exposure on enzymatic activity and gene expression changes in honey bees (Apis mellifera L.)
作者：Liu, Xuan;Wang, Chunxiao;Zhu, Wenchao;Wang, Xuejing;Wang, Zhixin;Gai, Xiaojun;Lv, Lu;Wang, Yanhua
关键词：Pesticide mixture; Synergistic toxicity; Pollination insects; Biomarker
-
Environmental concentrations of TCEP and TDCIPP induce dysbiosis of gut microbiotal and metabolism in the honeybee (Apis mellifera L.)
作者：Cang, Tao;Lv, Lu;Wu, Changxing;Wang, Yanhua;Gu, Weijie;Jin, Yuanxiang;Zhu, Yu-Cheng;Guo, Mingcheng
关键词：Pollination insect; Gut microbial communities; Organophosphorus flame retardants; Metabolic disturbance
-
Evaluation of tobacco pesticides nitenpyram-spiroxamine co-exposure effects on honeybees: Molecular mechanisms and melatonin's protective role
作者：Wang, Hancheng;Cai, Liuti;Xue, Yuan;Wang, Ying;Pan, Shouhui;Zhu, Jun;Wang, Yanhua
关键词：Pesticide; Honeybee; Synergistic toxicity; Co-exposure; Midgut
-
Synergistic disruption of detoxification, immunity, and neural pathways in honeybees following co-exposure to cyantraniliprole and difenoconazole
作者：Liu, Xuan;Zhu, Wenchao;Gai, Xiaojun;Liu, Shaoqing;Wang, Chunxiao;Wang, Xuejing;Lu, Zeqi;Wang, Zhixin;Lv, Lu;Wang, Yanhua
关键词：Mixture effect; Bee ecotoxicology; Pesticide; Toxic mechanism
